ObjectiveTo explore the effect of fluoxetine on depression Depression State after cerebral infarction. Methods 60 cases of patients with depression after cerebral infarction were randomly divided into treatment and control groups, and each group was 30 patients. Two groups were given neural medical therapy and conventional acupuncture therapy as basic treatment. The treatment group added fluoxetine in the basic treatment. The control group accepted conventional therapy. The therapeutic effects were evaluated by the Hamilton Depression Scale (HAMD), National Institutes of Health Stroke Scale(NIHSS) and Barthel Index(ADL).Results Degrees of HAMD, NIHSS and ADL were improved in the two groups after treatment, and the differences were statistically signiifcant (P<0.01).ConclusionFluoxetine treatment in depression state after cerebral infarction has a good clinical efficacy, it can reduce the NIHSS, improve depressive symptoms and ADL independence.%目的观察西药盐酸氟西汀对脑梗死后抑郁状态的作用。方法筛选脑梗死抑郁状态患者60例，随机分为两组（治疗组和对照组），每组患者各30例。各组在采用神经内科常规治疗基础上，治疗组给予盐酸氟西汀治疗。观察组给予神经内科常规治疗。评价指标选用HAMD-17项评分、神经功能缺损程度评分和Barthel指数评分。结果对照组、治疗组评价指标与治疗前相比均明显改善（P＜0.01），具有显著统计学意义，且治疗组与对照组比较（P＜0.05），具有统计学意义。结论盐酸氟西汀治疗对脑梗死抑郁状态具有较好治疗作用，能够改善抑郁状态，提高日常生活活动能力。
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