Objective To investigate the clinical distribution and resistance of MRSA in 2009 to 2014 so as to provide basis data for clinical treatment. Methods 206 non-repetitive MRSA from sputum were tested identification and the antimicrobial resistance by VITEK-2 Auto Microbe System. Results 206 MRSA from sputum were collected in 2009 to 2014, 40 were from children, and 166 were from adult. Those the resistant rate of the children MRSA was greater than 50% were ampicillin-sulbactam, penicillin G, erythromycin, while those the resistant rate of the adult MRSA was greater than 50% were ampicillin-sulbactam, penicillin G, levofloxacin, ciprofloxacin, erythromycin, moxifloxacin, clindamycin mold, gentamicin, tetracycline, rifampicin. The drug resistant rates of MRSA in children were significantly lower than those of MRSA in adult. Two hundred and six isolates were mainly distributed in ICU, department of respiration, pediatrics. Conclusion The drug resistant rates of MRSA in children were significantly lower than those of MRSAin adult, and clinicians need to choose reasonable drugs so as to slow the emergence of the drug resistant isolates.%目的：回顾分析2009～2014年医院分离的痰培养 MRSA 临床分布及耐药，为临床抗菌素选择提供依据。方法对痰培养、非重复金黄色葡萄球菌，采用 VITEK-2全自动微生物分析仪及配套鉴定卡对临床分离菌株进行鉴定和药敏实验。结果2009～2014年共收集了206株 MRSA，其中40株为儿童 MRSA，166株为成人 MRSA。206株 MRSA 主要分布于 ICU 病区、呼吸内科、儿科，分别占28.16%、15.05%、11.65%。在被检测的16种抗菌药物中，儿童 MRSA 耐药率大于50%分别为氨苄西林/舒巴坦、青霉素 G 及红霉素。成人 MRSA耐药率大于50%分别为氨苄西林/舒巴坦、青霉素 G、环丙沙星、左氧氟沙星、红霉素、莫西沙星、氯洁霉素、庆大霉素、四环素、利福平。儿童 MRSA 的耐药率明显低于成人 MRSA（有统计学差异）。结论儿童 MRSA 的耐药率明显低于成人 MRSA，临床医生需选择合理抗菌素进行相应的抗感染治疗，已减缓耐药菌产生。
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