目的：探讨小剂量奥氮平联合帕罗西汀对老年期抑郁症治疗的临床效果。方法方便选取2012年1月―2016年1月该院收治的老年期抑郁症102例进行分组研究，按照计算机数字法分为对照组和治疗组，每组51例患者，对照组单独采用帕罗西汀进行治疗，治疗组采用小剂量奥氮平联合帕罗西汀治疗，采用HAMD量表和TESS量表对两组治疗效果和不良反应情况进行评价和比较。结果治疗组治疗后2周的HAMD评分为(21.39±2.47﹚分，治疗4周的HAMD评分为(16.29±3.28﹚分，治疗8周的HAMD评分为(9.52±2.40﹚分；对照组分别为(17.28±2.38﹚分、(11.29±3.18﹚分、(7.93±2.00﹚分，经比较，对照组治疗2周、4周的HAMD评分依然高于治疗组(P<0.05﹚，但两组治疗8周后的HAMD评分相比，差异无统计学意义(P>0.05﹚；治疗组总有效率94.1%明显高于对照组72.5%，组间差异具有统计学意义(P<0.05﹚。结论老年期抑郁症患者应用小剂量奥氮平联合帕罗西汀治疗方案，可在短时间内有效改善临床症状，进一步提高治疗效果，且安全有效，值得临床使用和推广。%Objective To observe the clinical effect of small dose of olanzapine combined with Pa Rossi Dean on the treat-ment of senile depression. Methods From January 2012 to January 2016 in our hospital for senile depression 102 cases were divided into two groups and studied, divided into control group and treatment group according to the computer digital method, each among 51 patients and control group separately using paroxetine treatment, the treatment group with small dose of olanzapine combined with paroxetine in the treatment by HAMD and Tess, evaluates and compares the two groups curative effect and adverse reaction. Results Convenient selection after treatment for 2 weeks HAMD score was (21.39 ± 2.47) points, for 4 weeks HAMD score was (16.29 ± 3.28) points, for 8 weeks HAMD score was (9.52 ± 2.40) points; the control group were (17.28 ± 2.38) points, (11.29 ± 3.18) points, (7.93 ± 2.00) points, by comparison, the control group 2 weeks, 4 weeks HAMD score is still higher than the treatment group (P<0.05), but the two groups 8 weeks after HAMD score, the difference was not statistically significant (P>0.05); the treatment group, the total efficiency of 94.1% was signifi-cantly higher than 72.5%, a significant difference between the groups was statistically significant (P<0.05) [see given the study of specific data, and to make consequential amendments] in the English summary. Conclusion Senile depression in patients with small dose olanzapine combined with paroxetine in the treatment scheme can effectively ameliorate clinical symptoms in a short period of time, in order to improve the therapeutic effect. It is safe and effective, and worthy of clinical application and promotion.
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