Objective To provide the basis for the primary prevention of Cervical cancer for in Jinzhou region.Method To detect the high-risk human papilloma virus(HPV)subtypes of 12805 women in Jinzhou district by the nucleic acid molecule rapid conductivity hybridization and To analyze Cervical cancer lesion before and cervical cancer related factors by filling out the questionnaire.Result HPV 16、58 、52 are the top 3 of the infection rate in Jinzhou district.The peak age of Cervical intraepithelial neoplasia(CIN)III and Cervical cancer is 41-50.The prevalence of HPV infection increases with the severity of the cervical disease.Early sexual life,multiple partners and HPV infection are the high risk factors of Cervical cancer.Conclusion The effective prevention and treatment effect of Cervical cancer can be obtained,by using targeted vaccines according to the types of HPV infection in different regions.%目的 探讨锦州地区妇女宫颈癌一级预防的相关依据.方法 采用核酸分子快速导流杂交基因芯片技术检测锦州地区12805名妇女高危型人类乳头瘤病毒(human papilloma virus,HPV)感染的主要亚型;通过填写调查问卷分析宫颈癌、癌前病变相关因素.结果 本地区妇女以HPV16、58、52型感染率最高,宫颈上皮内瘤变III级及宫颈癌高峰年龄均在41-50岁,HPV感染阳性率随着宫颈病变严重程度而升高,初次性生活过早、多性伴、HPV感染是宫颈癌的高危因素.结论 应根据不同地区高危HPV感染的类型有针对性地进行疫苗应用,才能取得良好的宫颈癌防治效果.
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