Objective To discuss the clinical manifestations,diagnosis,treatment and prognosis of congenital syphilis in newborn infants.MethodsThe clinical data of 50 cases of neonatal congenital syphilis were analyzed retrospectively from January 2013 to June 2015 in our hospital.ResultsThe clinical manifestations of neonatal congenital syphilis were skin and mucous membrane damage,jaundice,hepatosplenomegaly,liver damage,etc,clinical diagnosis by hemagglutination reaction detection of Treponema palidum antibody(TPHA)and rapid plasma reagin(RPR)test results were positive and can be diagnosed as congenital syphilis in this experiment,penicilin was used in the treatment of neonatal congenital syphilis,3 cases gave up treatment,45 of 47 cases were cured,2 cases were died,TPHA of twelve months was 47.62%,RPR was 95.24%.Conclusion If the newborn has skin and mucosa damage,jaundice,liver damage and other symptoms,they should be highly suspected of congenital syphilis,and given early diagnosis and treatment.%目的：探讨天性梅毒新生儿的临床表现、诊断情况、治疗方法和预后。方法回顾性分析我院2013年1月～2015年6月收治的50例天性梅毒新生儿的临床资料。结果天性梅毒新生儿的临床表现多为皮肤粘膜受损、黄疸、肝损害、肝脾肿大等；临床诊断以血球凝集反应侦测梅毒螺旋体抗体（TPHA）和快速血浆反应素试验（RPR）的检测结果均为阳性即可确诊为先天性梅毒新生儿；本次实验使用青霉素治疗先天性梅毒新生儿，3例放弃治疗，47例接受治疗的患儿中痊愈45例，死亡2例；预后效果中，12个月复查的TPHA转阴率为47.62%，12个月复查的RPR转阴率为95.24%。结论若新生儿出现皮肤粘膜受损、黄疸、肝损害等症状应高度怀疑先天性梅毒，应及早进行诊断和治疗。
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