精准医疗是近年来围绕生物信息学、分子医学、临床诊断学、医学影像学等学科发展起来的新型医学模式，是指针对患者的病情，通过前沿技术手段精确判定疾病的成因及确定治疗方案。最终目标为在医疗相关的各个领域内提升诊断能力、医疗水平及护理效果，实现个性化医疗。荧光分子成像是实现精准医疗的重要技术之一，与传统的结构成像不同，荧光分子影像可以提供生物体内的功能信息，可以在细胞和分子水平对生物体内的生理、病理变化过程进行在体成像。本文以精准医疗为背景，根据近年来国内外相关的研究进展，对荧光分子成像系统与重建算法进行了总结与综述，并阐述了其应用前景与价值。%As a newly developed medical model based on bioinformatics, molecular medicine, clinical diagnostics and medical imaging, precision medicine makes use of advanced technology to accurately trace causes of diseases and thusdetermine therapeutic regimen for different patients. The ultimate aim of precision medicine is to facilitate the diagnosis capability, medical treatment capability, and nursing effect in all medical-related ifelds, and to ifnally realize personalized medicine. Fluorescence molecular imaging is an essential technology involved in the realization of precision medicine. It provides in vivo functional information as well as imaging in cellular and molecular levels, which differs from traditional structural imaging. Based on recent development of related research both at home and abroad, this paper summarizes the reconstruction algorithms and imaging systems for lfuorescence molecular imaging and describes the value and future of the application with precision medicine as background.
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