In order to measure osteoporosis cases in animal clinical trials, the research developed a trabecular bone parameters measurement software system based on MircoCT images. On the premise of keeping skeletal structure intact, the paper carried on MicroCT scan on 12 samples of adult pig frontal bones and maxillary bones. Based on the two-dimensional sectional images, measurement of parameters such as bone density and trabecular thickness was conducted through the process of data import, three-dimensional visualization, and delineation of region of interests, and binary image processing. The results of the measurement was compared with BoneJ, which conifrmed the accuracy of measurement system (relative error <5% for each parameter). The system also allowed intuitive visualization and had a high application value in terms of animal trabecular parameter measurement.%为了更全面便捷地衡量动物临床试验骨质疏松情况,开发了一套基于MircoCT图像的用于测量骨小梁参数的软件系统。在保留骨结构完好的前提下,使用12组成年猪额骨及颌骨样本进行MicroCT扫描成像,并根据二维断层图像,经过导入数据、三维可视化、圈定感兴趣区、二值化处理等步骤后进行骨密度、骨小梁厚度等参数测量。测量结果与BoneJ进行对比,结果验证了本系统具有较高的测量准确性(各项参数相对误差均<5%),可视化效果直观,在动物骨小梁参数测量方面具有较高的应用价值。
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机译:analisi microtomografica del Tessuto Osseo Trabecolare:流感della soglia di Binarizzazione sul Calcolo dei parametri Istomorfometrici(骨小梁骨组织的显微图像分析:二值化水平对组织形态参数计算的影响)