ObjectiveToexploretheapplicationvalueofechocardiographyinevaluatingcardiac structureandfunctionofratswithalcoholiccardiomyopathy (ACM). Methods45maleWistarrats wererandomlydividedintonormalgroup (n=10)andACMgroup (n=35).ACMgroupweredivided into 2-monthgroup (n=10), 4-monthgroup (n=12)and 6-monthgroup (n=13).RatsfromACMgroup were gavaged with alcohol, and then let them drink alcohol at will, while rats from normal group were gavagedwithsalineatthesametimewiththesamedose.Thenratsfrom 2-monthgroup, 4-monthgroup and 6-monthgroupwereexaminedbyechocardiography,andtheresultswerecomparedwiththatofnormal group. All the rats were killed after examination. Heart tissues of those dead rats were took out for pathological examination,andtheresultsofultrasoundexaminationandpathologicalexaminationwerecompared. ResuIts Therewasnosignificantdifferencebetweenratsfrom 2-monthgroupandnormalgroup.Compared withthenormalgroup,LVPWDd,IVSDd,LVEDd,LVMandLVM/BMofratsfrom 4-monthgroup increased,whileEmandEm/Amdecreased,thedifferenceswereallsignificant (P<0.05).Compared withthenormalgroup,LVPWDd,IVSDd,EF,FS,Em,andEm/Amofratsfrom 6-monthgroup decreased, while LVM, LVM/BM and LVEDd increased, which were of significant difference (P<0.05).TheLVMmeasuredbyultrasoundwascloselyrelatedtoautopsyresults (r=0.84,P<0.05). Accordingtopathologicalresults,theHEstainingin 2-monthACMratsandnormalratswere normal,whilethatof 4-monthACMratsand 6-monthACMratswererespectivelyinaccordance withthesubclinicalandclinicalperiodofACM. ConcIusionEchocardiographycanbeusedinthe quantitative and dynamical evaluation of the cardiac structure and function of rats with ACM.%目的：探讨超声心动图在评价酒精性心肌病大鼠心脏结构和功能中的应用价值。方法选取雄性Wistar大鼠45只，随机分为模型2月组（10只）、模型4月组（12只）、模型6月组（13只）及正常组（10只）。模型组进行酒精灌胃及酒精随意饮用；正常对照组选择相同时间及相同剂量生理盐水灌胃。分别于2个月、4个月、6个月后进行超声心动图检测，并将模型组与正常组超声结果进行对比。检测结束后处死模型组和正常组大鼠，取心脏组织进行病理检测，将超声结果与病理结果进行对比。结果经超声检查，模型2月组与正常组大鼠心脏超声比较未见明显差异。模型4月组与正常组相比，舒张末期左心室后壁厚度（LVPWDd）、舒张末期室间隔厚度（IVSDd）、左室舒张末期内径（LVEDd）、左室质量（LVM）、LVM与体质量之比（LVM/BM）增大，舒张早期心肌运动峰值速度（Em）、Em/Am减低，且均有显著性差异（P＜0.05）。模型6月组与正常组相比，LVPWDd、IVSDd减小，LVM、LVM/BM、LVEDd增大，射血分数（EF）、左室短轴缩短率（FS）明显减低，Em、Em/Am减低，且均有显著性差异（P＜0.05）。超声测定的LVM与尸检检测结果高度相关（r=0.84，P＜0.05）。经病理检查，模型2月组以及正常组大鼠心肌HE染色未见异常，模型4月组及6月组大鼠心肌HE染色分别符合亚临床期和临床期酒精性心肌病的改变。结论超声心动图可对酒精性心肌病大鼠的心脏结构和功能进行动态、定量的评价。
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