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首页> 中文期刊> 《中国医学装备》 >复发性宫颈癌调强放射治疗前18F-FDG PET-CT对治疗决策的影响

复发性宫颈癌调强放射治疗前18F-FDG PET-CT对治疗决策的影响

         
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目的:回顾性研究氟18-氟代脱氧葡萄糖正电子发射断层(18F-FDG PET)-CT对复发性宫颈癌患者调强放射治疗(IMRT)方案的影响.方法:选取36例治疗后复发的宫颈癌患者,在行IMRT前进行18F-FDG PET-CT检查,并在3周之内行CT或MR等常规影像学检查,分别根据常规影像(CI)及18F-FDG PET-CT勾画大体肿瘤体积(GTV)靶区,对比二者的体积差异.结果:在36例行18F-FDG PET-CT检查的复发宫颈癌患者中,18F-FDG PET-CT诊断复发宫颈癌患者的灵敏度、特异度及准确率分别为97.1%,100%和97.2%.18F-FDG PET-CT改变了61.1%(22/36)患者的治疗方案,其中14例患者仍进行了IMRT,但放射治疗靶区因PET-CT而发生了改变.结论:18F-FDG PET-CT对于复发的宫颈癌患者,是一项灵敏度、特异度及准确率较高的治疗前再分期诊断手段,改变了部分复发性宫颈癌患者的治疗方案.%Objective: The aim of this retrospective study was to evaluate the contribution of fluorine-18-fluoro-2-deoxyglucose positron emission tomography/computed tomography (18F-FDG PET-CT) for the plan of intensity-modulated radiation therapy (IMRT) on the patients with recurrent cervical carcinoma. Methods: A total of 36 patients with recurrent cervical carcinoma who were candidates for IMRT underwent the detection of 18F-FDG PET-CT before they received IMRT. And in three weeks, they received other routine imaging detections included of CT or MR. Besides, the target area of gross tumor volume (GTV) was delineated according to conventional imaging (CI) and 18F-FDG PET-CT, respectively, and the difference of volume between them was compared. Results: In the 36 patients with recurrent cervical carcinoma who underwent the detection of 18F-FDG PET-CT, the sensitivity, specificity and accuracy rate of them were 97.1%, 100% and 97.2%, respectively. The therapeutic decision of 61.1% of patients (22/36) were changed. Although other 14 patients still received IMRT, the target areas of radiotherapy in them also were changed due to PET-CT. Conclusion: 18F-FDG PET-CT is a valuable tool with higher sensitivity, specificity and accuracy rate for patients with recurrent cervical carcinoma, and it can change treatment plan in a part of them.

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