Objective:To analyze the effect of endoscopic submucosal tunnel dissection on patients with large esophageal superficial neoplasms.Methods: Chosen patients with large esophageal superficial neoplasms in our hospital as research object, randomly divided into control group treated by endoscopic mucosal dissection (ESD) and observation group treated by endoscopic submucosal tunnel dissection(ESTD), compared surgery related indicators, complications and treatment outcomes.Results: 1)Observation group patients’ tumor stripping rate (23.17±4.73)/min was significantly higher than control group patients’ (12.65±2.19)/min; Intraoperative blood loss(9.14±0.67)ml, total length of hospital stay (7.34±1.89) d, were significantly less than control group patients with intraoperative blood loss(21.38±3.14)ml, total length of hospital stay (13.21±3.05)d, t value was 4.965, 5.395, 4.932, respectively(t=4.965,t=5.395,t=4.932;P<0.05); 2)Observation group patients esophageal bleeding ESTD rate(5.26%), esophageal stricture rate(31.58%), mediastinal emphysema rate(5.26%), esophageal perforation rate of 0, were significantly less than control group patients with esophageal bleeding rate(31.58%), esophageal stricture rate(5.26%), mediastinal emphysema rate(21.05%), esophageal perforation rate (26.32%), t value were 4.378, 4.378, 4.471, 5.758, (t=4.378,t=4.378,t=4.471,t=5.758;P<0.05); 3)Observation group patients with no recurrence during the follow-up period, control group patients with local recurrence rate of 21.05%, t value 8.623,P<0.05(t=8.623, P<0.05).Conclusion: Endoscopic tunnel mucosal stripping technique can effectively improve the complete tumor removal rate, during the process of optimization operation at the same time reduce the occurrence of complications, to the improvement of the prognosis of patients with positive clinical significance.%目的：分析内镜下隧道式黏膜剥离术(ESTD)治疗食管大面积浅表肿瘤的临床疗效。方法：选择38例接受治疗的食管大面积浅表肿瘤患者，将其随机分为观察组与对照组，每组19例。对照组接受内镜黏膜剥离术(ESD)治疗；观察组接受(ESTD)治疗，比较两组患者的剥离速度、术中出血量及总住院时间等手术相关指标、手术并发症及治疗预后等情况差异。结果：①观察组的肿瘤剥离速度为(23.17±4.73)mm2/min，术中出血量为(9.14±0.67)ml、总住院时间为(7.34±1.89)d；对照组的肿瘤剥离速度为(12.65±2.19)mm2/min，术中出血量为(21.38±3.14) ml、总住院时间为(13.21±3.05)d，观察组的肿瘤剥离速度明显高于对照组，术中出血量和总住院时间明显少于对照组，两组相比差异有统计学意义(t=4.965，t=5.395，t=4.932；P＜0.05)；②观察组患者接受ESTD治疗后的食管出血、食管狭窄等并发症发生率明显少于对照组，两组相比差异有统计学意义(x2=4.378，x2=4.378；P＜0.05)；③观察组患者在随访期内无一例复发，对照组患者局部复发率为21.05%，两组相比差异有统计学意义(x2=8.623，P＜0.05)。结论：ESTD可以有效提高肿瘤完整剥除率，在优化手术过程的同时降低并发症的出现，对于患者预后的改善具有积极的临床意义。
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