Objective: To explore the effect on alanyl glutamine added total parenteral nutritionrn(TPN) on patients' nutrition and immune function of critical patients in surgical. Methods: 94rnpatients were assigned into treatment group and control group randomly. All patients underwentrnTPN for 8 d. Injection of alanyl glutamine was given to the treatment group with a dose of 0.4 g/rnkg. The level of nutrition index and immune index were determined and compared between prernTPN, 2 d and 8 d after TPN. Results: The level of ALB, PAB, TRF and PNI of both groups 2 d after TPN were bothrndecreased, the level of IgG, IgA, IgM, the percent of CD4, the ratio of CD4/CD8 both groups 2 d after TPN were allrnlower, the outcome of treatment group was better than control group . the difference on the level of above nutrition andrnimmune data of two groups in day 8 is statistically significant (t=2.235, t=2.167;P<0.05).In contrast, the results inrnthe percent of CD8 (t=2.178, P<0.01)increase. Conclusion: TPN added with alanyl glutamine is beneficial to criticalrnpatients in surgical, and can improve patient's nutrition, enhance their immune function.%目的:探讨全胃肠外营养(TPN)加丙胺酰-谷氨酰胺注射液对外科危重症患者营养及免疫功能的影响.方法:将94例外科重症需要TPN的患者随机分为治疗组和对照组,均给予8dTPN治疗,其中治疗组患者每天加用丙胺酰-谷氨酰胺注射液0.4 g/kg.检测患者TPN前、TPN后2 d及8 d的营养及免疫指标并进行分析.结果:治疗组、对照组与TPN前比较,TPN后2 d血清ALB、PAB、TRF水平、PNI均有不同程度恢复,CD4的百分比、CD4/CD8比值、IgG、IgA、IgM有不同程度下降,治疗组优于对照组,在TPN后8 d两组比较差异有统计学意义(t=2.235,t=2.167;P＜0.05);而CD8的百分比与上述相反(t=2.178,P＜0.01).结论:外科危重症患者在TPN治疗基础上加用丙胺酰-谷氨酰胺注射液能有效改善机体营养和免疫状况,从而促进预后.
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