目的：探讨调强适形放射治疗(IMRT)与三维适形放射治疗(3D-CRT)技术治疗原发性肝癌的临床剂量学。方法：选取入住本院的45例原发性肝癌患者，针对每例患者制定2套放射治疗计划，比较计划靶区(PTV)的平均剂量、最小剂量、最大剂量及最大剂量与处方剂量的百分比、靶区适形指数以及靶区均匀指数，分析危及器官的照射剂量。结果：统计分析显示，最小受照剂量(PTVDmin)中，两者差异无统计学意义(t＝0.037，P＞0.05)；平均受照剂量(PTVDmean)、最大受照剂量(PTVDmax)、靶区最大剂量与处方剂量的百分比(PTVDmax/%)、靶区剂量均匀度指数(HI)和适形度指数(CI)IMRT 与3D-CRT差异均具有统计学意义(t＝35.631，t＝4.136，t＝3.428，t＝2.123， t＝15.996；P＜0.05)。危及器官的照射剂量分析中，IMRT在肾脏、胃、十二指肠和脊髓的剂量明显低于3D-CRT的照射剂量。结论：IMRT能有效地提高靶区的照射剂量，降低危及器官的损伤。%Objective: To explore the clinical dosimetry of intensity modulated radiation therapy(IMRT) and three dimensional conformal radiotherapy(3D-CRT) for hepatocellular carcinoma treatment. Methods: Firstly, making radiotherapy schemes of IMRT and 3D-CRT for each patient among 45 ones in our hospital. Secondly, comparing PTVDmean, PTVDmin, PTVDmax, PTVDmax%, CI and HI. Finally, analyzing the dosage which endangers patient’s organs. Results: Comparation analysis results show that there is no statistical difference in PTVDmin (t=0.037,P>0.05), but there is significant statistical difference in PTVDmean, PTVDmax, PTVDmax/%, HI and CI between IMRT and 3D-CRT (t=35.631,t=4.136,t=3.428,t=2.123,t=15.996;P<0.05). Dosage analysis results show that IMRT remains in kidney, small intestine and spinal cord is remarkably less than the 3D-CRT. Conclusion:IMRT can effectively increase the radiation dose in target areas, reduce organ damage, and improve life quality of the patients.
展开▼
