目的：研究导管介入封堵与外科微创封堵治疗单纯继发孔房间隔缺损的临床疗效。方法：选择80例单纯继发孔房间隔缺损患者作为研究对象，随机分为给予导管介入封堵治疗的观察组和外科微创封堵治疗的对照组，每组各40例，观察其手术相关指标和心功能指标。结果：两组患者的手术成功率等相关指标差异无统计学意义(x2＝1.039，P＞0.05)；手术成功与年龄呈负相关、与左室射血分数LEVF呈正相关(t＝7.832，P＜0.05)，与性别无相关关系(t＝0.892，P＞0.05)；＞45岁的入组患者中，观察组的成功率高于对照组(x2＝5.728，P＜0.05)；左心室舒张末期直径、射血分数明显高于对照组(t＝5.372，t＝5.382；P＜0.05)。结论：导管介入封堵与外科微创封堵治疗均能取得理想的治疗效果，其中导管介入封堵具有手术创伤小的优势，在年龄＞45岁的患者中具有积极的临床价值。%Objective:To study effect of transcatheter occlusion and minimally invasive surgical occlusion in treating secundum atrial septal defect. Methods:Patients with secundum atrial septal defect were collected and randomly divided into observation group given transcatheter occlusion and control group received minimally invasive surgical occlusion. Then operation related index and and heart function index were observed. Results: there were no differences in operation related index between two groups(x2=1.039, P>0.05);operation success had negative correlation with age and positive correlation with LEVF (t=7.832, P<0.05) and no correlation with sex(t=0.892, P>0.05);in patients older than 45, the successful case, LEVF and LVEDD of observation group were significantly higher than control group(t=5.372, t=5.382;P<0.05). Conclusion:transcatheter occlusion and minimally invasive surgical occlusion can achieve ideal therapeutic efficacy;transcatheter occlusion has positive clinical value in patients over 45 years old for its advantages of small operation wound.
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