目的 观察臭氧大自血自体回输疗法治疗脑梗死急性期的临床效果.方法 收集2015年1～12月广西中医药大学附属瑞康医院神经内科一病区住院的脑梗死急性期患者80例,采用随机数字表法分为对照组和治疗组,每组40例.两组患者均给予常规治疗,在此基础上,治疗组加用臭氧大自血自体回输疗法,取患者静脉血200 mL离体与浓度为20～30μg/mL臭氧混合后回输体内,3次/周,21d为1个疗程.比较两组治疗前后的神经功能缺损评分及疗效.结果 两组治疗前美国国立卫生研究院卒中量表(NIHSS)比较,差异无统计学意义(P＞ 0.05).两组治疗后NIHSS均较治疗前降低,差异有统计学意义(P＜0.05).治疗组治疗后NIHSS低于对照组,差异有统计学意义(P＜0.05).治疗组总有效率显著高于对照组,差异有统计学意义(P＜0.05).结论 在脑梗死急性期常规治疗的基础上加用臭氧大自血自体回输法,可改善患者的神经功能缺损,提高治疗总有效率,值得临床推广应用.%Objective To observe clinical effect of ozone major auto-hemo-therapy in the treatment of patients with acute ischemic stroke.Methods 80 patients with acute ischemic stroke in Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine from January to December 2015 were selected and divided into control group and treatment group by a random digital table,with 40 cases in each group.Conventional therapy was used in both groups.On this basis,the patients in treatment group were given ozone major auto-hemo-therapy with 200 mL venous blood,which previously exposed to a concentration of 20-30 μg/mL O2-O3 mixture,three times a week for 21 days.Neurological deficit score before and after treatment and clinical effect were compared between two groups.Results Before treatment,NIHSS between two groups was not statistically significant difference (P ＞ 0.05).After treatment,NIHSS in two groups were lower than before treatment,with statistically significant difference (P ＜ 0.05).After treatment,NIHSS in treatment group was lower than that in control group,with statistically significant difference (P ＜ 0.05).Total effective rate in treatment group was significantly higher than that in control group,the difference was statistically significant (P ＜ 0.05).Conclusion The ozone major auto-hemo-therapy and conventional treatment can improve functional level of neurological defects and total effective rate in patients with acute ischemic stroke.It is worthy of clinical promotion and application.
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