Objective To observe the clinical effect of continuous regional arterial infusion combined with Houpupaiqi Mixture in the treatment of severe acute pancreatitis.Methods From December 2014 to December 2016,in Dongguan Kanghua Hospital,the clinical data of 42 patients with severe acute pancreatitis were retrospectively analyzed.The control group (n =22) was treated with conventional Western Medicine,the treatment group (n =20) was treated with continuous regional arterial infusion combined with Houpupaiqi Mixture.The white blood cell count,blood amylase value,blood glucose level,and APACHE Ⅱ score were compared between the two groups on the day of admission,the fifth day and tenth day of treatment.The two groups of patients after treatment of abdominal pain relief time,total length of hospital days and hospital total cost of two groups were compared.Results There were no significant differences in white blood cell count,blood glucose level,serum amylase value and APACHE Ⅱ score between the two groups on the day of admission (P ＞ 0.05).After treatment,the patients with white blood cell count,blood glucose level,blood amylase value and APACHE Ⅱ score were lower than those before admission,the differences were statistically significant (P ＜ 0.05).The white blood cell count,blood glucose level,blood amylase value and APACHE Ⅱ score of the treatment group were significantly lower than those of the control group on the 5th day and the 10th day of treatment,the differences were statistically significant (P ＜ 0.05).Compared with the control group,the treatment group had shorter abdominal pain relief time,less total hospitalization days and lower hospitalization costs,and the difference were statistically significant (P ＜ 0.05).Conclusion Continuous regional arterial infusion combined houpupaiqi mixture in treatment of severe acute pancreatitis is superior to that of simple western medicine conventional therapy,significantly improve the clinical efficacy,shorten the hospitalization day,and it is worthy to be popularized.%目的 观察连续性区域动脉灌注联合厚朴排气合剂治疗重症急性胰腺炎的临床疗效.方法 回顾性分析东莞康华医院2014年12月～2016年12月重症急性胰腺炎患者42例的临床资料,对照组(n=22)应用西医常规治疗方法,治疗组(n=20)运用连续性区域动脉灌注联合厚朴排气合剂治疗.比较两组入院当天、治疗第5天、治疗第10天的白细胞计数、血淀粉酶值、血糖值、APACHEⅡ评分情况;比较两组患者经治疗后腹痛缓解时间、总住院天数及住院总费用情况.结果 两组患者入院当天白细胞计数、血糖水平、血淀粉酶值及APACHEⅡ评分差异不大,差异无统计学意义(P＞0.05);两组治疗后患者白细胞计数、血糖水平、血淀粉酶值及APACHEⅡ评分较入院前降低,差异有统计学意义(P＜0.05);治疗第5天、第10天治疗组患者白细胞计数、血糖水平、血淀粉酶值及APACHEⅡ评分较对照组明显降低,差异有统计学意义(P＜0.05);治疗组较对照组腹痛缓解时间短、总住院天数少、住院费用低,差异有统计学意义(P＜0.05).结论 连续性区域动脉灌注联合中药治疗重症急性胰腺炎优于单纯西医常规治疗,明显提高临床疗效,缩短住院时间,值得临床推广.
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