目的 探讨吴茱萸+芒硝外用辅助干预对重症胰腺炎患者全身炎性反应程度、靶器官损伤程度的影响.方法 收集2013年2月～2017年1月广东省中医院收治的重症胰腺炎患者80例,按照单盲随机对照法将入组患者分为两组,每组各40例.对照组接受常规治疗,观察组在此基础上加入吴茱萸+芒硝外用辅助干预.入院即刻、治疗1周后,采用酶联免疫吸附法(ELISA)测定血清炎症指标含量,采用半自动生化分析仪检测血清肝功能指标含量,采用分光光度计法检测血清肠黏膜屏障指标含量.结果 入院即刻,两组全身炎性反应程度、肝功能及肠黏膜屏障功能比较差异无统计学意义(P＞0.05).治疗1周后,两组患者血清中白介素-6(IL-6)、白介素-8(IL-6)、单核细胞趋化蛋白-1(MCP-1)、谷丙转氨酶(ALT)、总胆红素(TBiL)、碱性磷酸酶(AKP)、D-乳酸、二胺氧化酶(DAO)、内毒素的含量低于入院即刻,且观察组血清中IL-6、IL-8、MCP-1、ALT、TBiL、AKP、D-乳酸、DAO、内毒素的含量低于对照组(P＜0.05).结论 吴茱萸+芒硝外用辅助干预可缓解重症胰腺炎患者的全身炎性反应程度,保护靶器官功能.%Objective To study the influence of external adjuvant application of Fructus Evodiae plus Natrii Sulfas on the degree of systemic inflammatory response and target organ damage in patients with severe acute pancreatitis.Methods Eighty cases of patients with severe acute pancreatitis admitted to Guangdong Hospital of Traditional Chinese Medicine from February 2013 to January 2017 were collected,and the enrolled patients were divided into two groups by single blind randomized controlled method,with 40 cases in each group.The control group received conventional therapy,on basis of which,the observation group was added with external adjuvant application of Fructus Evodiae plus Natrii Sulfas.At admission,one week after treatment,the contents of serum inflammatory indexes were measured by enzyme linked immunosorbent assay (ELISA),the contents of serum liver function indexes were detected by semi automatic biochemical analyzer,the contents of intestinal mucosal barrier indexes were measured by spectrophotometer method.Results At admission,there were no significant differences in the degree of systemic inflammatory response,liver function and intestinal mucosal barrier function between the two groups (P ＞ 0.05).One week after treatment,the contents of serum interleukin-6 (IL-6),interleukin-8 (IL-6),monocyte chemoattractant protein-1 (MCP-1),alanine aminotransferase (ALT),total bilirubin (TBiL),alkaline phosphatase (AKP),lactic acid,D-amine oxidase (DAO),endotoxin of the two groups were significantly lower than those at admission,and the contents of serum IL-6,IL-8,MCP-1,ALT,TBiL,AKP,D-lactic acid,DAO,endotox of observation group were significantly lower than those of control group (P ＜ 0.05).Conclusion External adjuvant application of Fructus Evodiae plus Natrii Sulfas can alleviate the degree of systemic inflammatory response in patients with severe acute pancreatitis,and protect target organ function.
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