Objective To study and investigate the clinical value of thrombelastogram for the evaluation of coagulation function and prediction of metastasis in patients with moderate and advanced breast cancer.Methods One hundred and fourteen patients with moderate and advanced breast cancer admitted to Liaoning Cancer Hospital ("our hospital" for short) from January 2016 to January 2017 were selected and divided into two groups,with 56 cases in group Ⅰ (Ⅰ + Ⅱ stage of patients with breast cancer) and 58 cases in group Ⅱ (Ⅲ +Ⅳ stage of patients with breast cancer),of which,there were 18 cases with metastasis (metastasis group) and 40 cases without metastasis (no metastasis group) in group Ⅱ.Another 50 healthy controls in our hospital at the same time were selected as normal control group.The thrombelastogram was used to detect response time (R value),coagulation time (K value),maximum amplitude (MA value),angle.The prothrombin time (PT),activated partial thromboplastin time (APTT),fibrinogen (FIB) and thrombin time (TT) were tested by routine examination.Results The R value,K value,MA value,angle in group Ⅰ,Ⅱ were all higher than those of normal control group,and R value,K value,MA value,angle in group Ⅱ were all higher than those of group Ⅰ,the differences were all statistically significant (all P ＜ 0.05).The PT,APTT,TT,FIB in group Ⅰ,Ⅱ were all higher than those of normal control group,but the differences were not statistically significant (P ＞ 0.05),there were also no statistically significant differences of PT,APTT,TT,FIB between group Ⅰ and group Ⅱ (P ＞ 0.05).The R value,K value,MA value,angle in metastasis group were all higher than those of no metastasis group,the differences were all statistically significant (P ＜ 0.05),while there were no statistically significant differences of PT,APTT,TT,FIB between metastasis group and no metastasis group (P ＞ 0.05).Conclusion Compared with routine coagulation function examination,thrombelastogram can evaluate the coagulation function of breast cancer more effectively,which has an important value for prediction of breast cancer metastasis.%目的 研究和探讨血栓弹力图对中晚期乳腺癌患者凝血功能的评价及预测转移的临床价值.方法 选择2016年1月～2017年1月辽宁省肿瘤医院(以下简称“我院”)收治的1 14例中晚期乳腺癌患者,将其分为两组,Ⅰ组(Ⅰ+Ⅱ期乳腺癌患者)56例,Ⅱ组(Ⅲ+Ⅳ期乳腺癌患者)58例,其中Ⅱ组发生转移18例(转移组),未发生转移40例(未转移组).另选择我院同期50名健康体检者作为正常对照组.应用血栓弹力图检测反应时间(R值)、凝血时间(K值)、最大振幅(MA值)、Angle角,常规检查凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)浓度和凝血酶时间(TT).结果 Ⅰ、Ⅱ组R值、K值、MA值、Angle角均显著高于正常对照组,且Ⅱ组R值、K值、MA值、Angle角均显著高于Ⅰ组,差异均有统计学意义(均P＜0.05).Ⅰ、Ⅱ组PT、APTT、TT、FIB均高于正常对照组,但差异无统计学意义(P＞0.05),Ⅰ组与Ⅱ组PT、APTT、TT、FIB水平比较,差异亦无统计学意义(P＞0.05).转移组R值、K值、MA值、Angle角均显著高于未转移组,差异有统计学意义(P＜0.05).转移组与未转移组PiT、APTT、TT、FIB水平比较,差异无统计学意义(P＞0.05).结论 血栓弹力图较常规凝血功能检查能更有效地评价乳腺癌的凝血功能,对于预测乳腺癌转移具有重要的临床价值.
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