目的：研究传染病医院新的、严重的药品不良反应(ADR)发生的特征和规律。方法对2012~2014年石家庄市第五医院上报的所有严重的(含新的、严重的)ADR报告进行分析。结果从给药途径看，注射(34例，占54.0%)和口服(27例，占42.9%)易引发严重的ADR；从药品分类看，严重的ADR涉及药品种类以抗结核药(15例，占23.8%)、抗病毒药(15例，占23.8%)最多；从严重的ADR临床表现看，以肝细胞损害(4例)、肝衰竭(3例)、皮炎皮疹(4例)、发热(4例)等表现为主。结论传染病医院的ADR有其自身的特点，临床应加强新的严重的ADR监测和上报。%Objective To study the characteristics and regularity of new and serious adverse drug reaction (ADR) in in-fectious hospital. Methods All reports since 2012 to 2014 about new and serious ADR (including new serious) in the Fifth Hospital of Shijiazhuang City were analyzed. Results From the perspective of route of administration, injection (34 cases, 54.0%) and oral preparations (27 cases, 42.9%) more likely caused serious ADR. From the perspective of drug types, most of serious ADR were induced by anti-tuberculosis drugs (15 cases, 23.8%) and antiviral drugs (15 cases, 23.8%). Clinical manifestations of serious ADR mainly contained hepatocyte injury (4 cases), hepatic failure (3 cases), dermatitis or rash (4 cases), and fever (4 cases), etc. Conclusion The ADR in infectious hospital has its own character-istics, clinic should strengthen the new and serious ADR monitoring and reporting.
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