Objective To explore the effects of comprehensive nursing on the depression and the life quality of elderly patients with acute myocardial infarction. Methods Eighty nine elderly patients with acute myocardial infarction, from April 2012 to May 2014 in Pujiang Hospital, the Third People's Hospital of Chengdu, were selects as the research ob-jects. They were divided into control group (45 cases) and observation group (44 cases) according to different nursing methods, the control group was given the conventional care, and observation group was given the comprehensive nursing intervention on the basis of nursing of the control group. Before and 3, 6 months after intervention, the depression state and quality of life of patients in two groups were evaluated by Hamilton depression scale (HAMD), general quality of life inventory(GQOLI-74), and the score of HAMD and GQOLI-74 were compared between two groups. Results HAMD, GQOLI-74 score of patients in two groups before the intervention had no statistically significant difference (P> 0.05);the differences were statistically significant (P< 0.05). 3, 6 months after intervention, HAMD scores of patients in the control group [(18.3±5.6), (16.7±7.1) scores] and the observation group [(12.4±4.9), (10.9±5.2) scores] were significantly decreased compared with before [(27.1±7.9), (26.7±8.1) scores], and the observation group was lower than that of the control group, the differences were statistically significant (P<0.05). 3, 6 months after intervention, GQOLI-74 scores of patients in two groups were increased significantly compared with before, and mainly in the three aspects of body function, psy-chological function and material function; 3 months after intervention, function scores of psychological and social of the observation group were higher than those of the control group; 6 months after intervention, the function scores of physi-cal and psychological in the observation group were higher than those of the control group, the differences were statisti-cally significant (P< 0.05). Conclusion Comprehensive nursing can obviously improve the depression state of elderly patients with acute myocardial infarction, improve the quality of life, and worthy of worthy of clinical application.%目的：探讨综合护理对老年急性心肌梗死患者抑郁及生活质量的影响。方法选择2012年4月~2014年5月成都市第三人民医院蒲江医院收到的老年急性心肌梗死患者89例为研究对象，根据不同的护理方法将其分为对照组(45例)和观察组(44例)，对照组采用急性心肌梗死患者常规护理，观察组在对照组护理基础上采用综合护理干预措施。干预前，干预后3、6个月，采用汉密尔顿抑郁量表(HAMD)、生活质量综合评定问卷(GQOLI-74)评分对两组患者进行抑郁情况及生活治疗评估，比较治疗干预前后两组患者的HAMD、GQOLI-74评分。结果干预前，两组患者HAMD、GQOLI-74评分比较，差异均无统计学意义(P>0.05)；干预后3、6个月HAMD评分，对照组[(18.3±5.6)、(16.7±7.1)分]及观察组[(12.4±4.9)、(10.9±5.2)分]均较干预前[(27.1±7.9)、(26.7±8.1)分]明显降低，且观察组低于对照组，差异均有统计学意义(P<0.05)。两组患者干预后3、6个月的GQOLI-74评分均较干预前明显提高，主要体现在躯体功能、心理功能、物质生活功能三个方面；干预后3个月，观察组心理功能和社会功能评分均高于对照组；干预后6个月，观察组躯体功能和心理功能评分均高于对照组，差异均有统计学意义(P<0.05)。结论综合护理可明显改善老年急性心肌梗死患者抑郁情况，提高患者的生活质量，值得临床推广应用。
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