Objective To discuss the auxiliary therapeutic effects of repetitive transcranial magnetic stimulation (rTMS) on patients with depression. Methods 44 patients with CCMD-3 diagnosed depression admitted to Wuxi Mental Health Center Affiliated to Nanjing Medical University from October 2013 to March 2014 were randomly divided into study group (n= 22) and control group (n = 22). A combination of Sertraline and rTMS was adopted for the study group with a total number of 10 time and pure Sertraline treatment was applied to the control group. HAMD-24 was employed to score at baseline (before treatment) and at the end of the 2nd, 4th and 8th week. Adverse reactions were rated after the treatment of 8 weeks. Results The difference in HAMD-24 scores between the two groups was not statistically signifi-cant before treatment (P>0.05). In the study group, the HAMD-24 scores after the treatment of 2, 4, 8 weeks were re-spectively (20.32±2.46), (14.41±2.04) points and (11.36±3.50) points, which were respectively (22.73±2.83), (16.36±1.79) points and (13.41±3.13) points in the control group. Therefore, the differences in HAMD-24 scores between the two groups were statistically significant (P< 0.01 or P<0.05). The HAMD-24 scores at the end of 2nd, 4th and 8th week were lower than those before treatment in study group and control group (all P<0.01). The excellent efficiency in study group was 86.4%, with the total effect rate of 95.5%. The excellent efficiency in control group was 63.6%, with the total effect rate of 90.9%. The efficacy of study group and the control group had no statistical significance (χ2=5.50, P>0.05). There was no statistical significance of the incidence of adverse reactions at the end of 8th week between the study group and the control group (χ2=2.72, P>0.05). Conclusion High frequency rTMS has auxiliary therapy effect on depression.%目的：探讨重复经颅磁刺激(rTMS)对抑郁症患者的辅助治疗作用。方法将2013年10月~2014年3月南京医科大学附属无锡市精神卫生中心收治的符合中国精神障碍分类与诊断标准第3版(CCMD-3)抑郁症诊断标准的44例患者随机分为研究组(n=22)和对照组(n =22)。研究组给予舍曲林联合rTMS治疗，治疗总次数为10次。对照组给予单纯舍曲林治疗。在治疗前(基线)、治疗第2、4周以及8周末应用汉密尔顿抑郁量表(HAMD-24)进行评分；第8周末评定不良反应。结果治疗前两组间HAMD-24评分差异无统计学意义(P>0.05)。研究组治疗第2、4、8周HAMD-24评分[(20.32±2.46)、(14.41±2.04)、(11.36±3.50)分]与对照组[(22.73±2.83)、(16.36±1.79)、(13.41±3.13)分]比较，差异有统计学意义(P <0.01或P <0.05)。治疗第2、4、8周末研究组与对照组HAMD-24评分与治疗前比较均降低(均P<0.01)。研究组显效率为86.4%，总有效率为95.5%。对照组显效率为63.6%，总有效率为90.9%。两组疗效比较差异无统计学意义(χ2=5.50，P>0.05)。第8周末研究组与对照组不良反应发生率比较差异无统计学意义(χ2=2.72，P>0.05)。结论高频rTMS对抑郁症具有辅助治疗作用。
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