摘要:Objective :to tolbutamide will be observed the clinical efficacy of treatment of depression .Methods:randomly selected data from November 2012 to November 2013 of our hospital ,92 cases of patients with depression ,the average is divided into two groups ,control group treated with par-oxetine ,team with tolbutamide will benefit for treatment ,and the two groups of clinical data were retrospectively analyzed .Results :after treatment group total effectiveness 95 .65% ,obviously higher than the control group total effectiveness 76 .09% ,compare with statistically significant difference (P < 0 .05) .Group and control group in incidence of adverse reactions were 8 .69% ,10 .87% ,was no significant difference between groups (P > 0 . 05) .Conclusion :tolbutamide will benefit the clinical curative effect of treating depression is very significant ,can effectively improve the symptoms of depression ,anxiety patients ,improve patient quality of life ,is worth to be widely applied in clinical .%目的:对氨磺必利治疗抑郁症的临床疗效进行观察研究。方法:资料随机选自2012年11月~2013年11月我院收治的抑郁症患者92例,平均分为两组,对照组以帕罗西汀来进行治疗,研究组以氨磺必利进行治疗,并对两组临床资料进行回顾性分析。结果:经治疗后,研究组总有效率95.65%,明显高于对照组总有效率76.09%,比较有差异具有统计学意义(P<0.05)。研究组、对照组不良反应发生率分别为8.69%、10.87%,组间比较无明显差异(P>0.05)。结论:氨磺必利治疗抑郁症的临床疗效十分显著,可以有效改善患者抑郁、焦虑的症状,提升患者生活的质量,值得在临床中广泛推广应用。