目的 探讨重组人表皮生长因子治疗儿童口腔溃疡的疗效.方法 85例经临床确诊的口腔溃疡患儿随机分为研究组(n = 43)与对照组(n = 42),分别给予重组人表皮生长因子凝胶每天3次和冰硼散每天3次局部用药,比较两组患儿溃疡疼痛消失时间、溃疡愈合时间、进食改善时间、疗效及药物不良反应情况.结果 在两组患儿年龄、性别比、病程及溃疡面积均匹配(P ＞ 0.05)的基础上,研究组患儿疼痛消失时间、溃疡愈合时间及进食改善时间均显著短于对照组(t = 2.97、3.65、3.12,均P ＜ 0.05),治疗后总有效率(90.70%)显著高于对照组(59.52%)(χ2=11.96,P ＜ 0.01).两组治疗过程中均未发生明显不良反应,对照组局部用药即时,22例出现刺激痛加剧.结论 重组人表皮生长因子能够加快儿童口腔溃疡愈合,减缓疼痛,改善患儿进食情况,临床疗效好,无明显不良反应,值得临床推广使用.%Objective To explore the therapeutic effect of recombinant human epidermal growth factor (rhEGF) on dental ulcer of children. Methods 85 children with dental ulcer confirmed in clinic were divided into study group (n = 43) and control group (n = 42) at random, children in the two groups were received rhEGF gel three times a day and Bingpeng San three times a day, respectively. The ache disappeared time, healing time and recovery time of eating in the two groups were compared; moreover, the therapeutic effect and drug adverse reactions (ADR) of two groups were also evaluated. Results The age, sex, course and area of dental ulcer in two groups were matched (P > 0.05). The ache disappear time, healing time and recovery time of eating of study group were all statistically shorter than those of control group (t = 2.97, 3.65, 3.12, all P < 0.05), the total effective rate was also significantly higher than that of control group (90.70% vs 59.52%, χ2=11.96, P < 0.01). No obvious ADR in both groups was observed in the treatment, 22 children occurred immediately aggravation of stimulate pain. Conclusion rhEGF can accelerate the healing of dental ulcer for children, release ache, improve the situation of taking food, it gains good therapeutic effect and has no obvious ADR, thus it is worthy of extensively applied in clinic.
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