One case of endometrioid undifferentiated carcinoma with choriocacinomatous differentiation was observed clinically and pathologically with HE staining and immunohistochemistry. The results showed that, the endometrial neoplasia was about 3.0 cmx2.5 cm. The low-differentiated tumor cells were arranged in solid nets with scant stroma, marked atypi-cally, multinucleated syncytial cells and convoluted nuclei. The tumor cells stained positively for CK7 (+), syncytial cells negatively for ER(-), PR(-), CD68(-) positively for HCG(+). Endometrioid undifferentiated carcinoma with choriocacinomatous differentiation is a rare entity with features of higher malignant tumor, and the prognosis is difficult to be evaluated for rare cases reported.%通过对1例伴绒毛膜上皮癌分化的子宫内膜未分化癌进行临床、病理及免疫组化观察,结果发现,肿物大小约3.0 cm×2.5 cm,实性,质较硬,镜下肿瘤组织由分化差的上皮样细胞构成,癌细胞核大、异型,实性分布,间质少,可见多核合体细胞,核分裂多见.免疫组化显示瘤细胞CK7(+)、ER(-)、PR(-)、CD68(-),合体细胞HCG(+).这是一种罕见的恶性肿瘤,一般预后较差,由于文献报道例数有限,预后的评价尚待进一步统计分析.
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