目的 研究非甾体类抗炎药(NSAIDs)诱发上消化出血的临床特征.方法 调查亳州市人民医院2008年1月～2011年5月因诊断上消化道出血收住院治疗142例患者,根据入院前10 d内有无服用过NSAIDs的病史,将患者分为NSAIDs组(49例)及非NSAIDs组(93例)两组进行分析比较.结果 两组比较,患者的性别、消化道溃疡病史差异无统计学意义,但NSAIDs组患者在年龄、心血管病史、出血前消化道症状、血红蛋白含量、内镜下消化道溃疡、住院时间、72 h止血率等方面与非NSAIDs组比较,差异有统计学意义(P ＜ 0.05).结论 NSAIDs是上消化道出血的重要病因,年老、患有心脑血管疾病者更易出现并发症,且止血效果欠佳.应掌握NSAIDs类药物的适应证和禁忌证,可同时使用胃肠道保护药.%Objective To study the clinical features of the upper gastrointestinal bleeding caused by non-steroidal anti-inflammatory drugs (NSAIDs). Methods 142 cases diagnosed as upper gastrointestinal bleeding from January 2008 to May 2011 in Bozhou people's hospital were investigated. Patients were divided into NSAIDs group (49 cases) and non-NSAIDs group (93 cases) according to whether they had NSAIDs in ten days before admission. And the patients were analyzed and compared. Results The gender, history of peptic ulcer of the two groups were no significant different, but there were significant differences in the age, history of cardiovascular disease, gastrointestinal symptoms before the bleeding, hemoglobin concentration, endoscopic gastrointestinal ulcers, hospital stay, 72 hours to stop bleeding rate between NSAIDs groups and non-NSAIDs group (P < 0.05). Conclusion NSAIDs are an important cause of upper gastrointestinal bleeding, the elderly and those suffering from cardiovascular and cerebrovascular disease are more vulnerable to complications, and bleeding is ineffective. NSAIDs class of drugs should have the indications and contraindications, which can protect the gastrointestinal tract using drugs.
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