目的 观察并探讨硫酸氢氯吡格雷联合那曲肝素钙治疗不稳定型心绞痛临床效果及安全性.方法 选取我院2007年5月～2010年11月收治不稳定型心绞痛患者196例,将其随机分为两组,其中对照组98例,采用卧床休息,控制血压,阿司匹林、调脂药物口服及硝酸酯类药物静脉滴注等常规治疗,实验组98例,在对照组治疗基础上,采用硫酸氢氯吡格雷与那曲肝素钙联合治疗.治疗结束后评价临床疗效及不良反应发生情况.结果 实验组患者临床症状缓解及心电图改善总有效率明显高于对照组患者,组间比较差异有统计学意义(P ＜ 0.05);治疗后两组患者全血比黏度及血浆比黏度均明显下降,且实验组患者下降程度明显高于对照组,组间比较差异有统计学意义(P ＜ 0.05);同时对照组与实验组患者不良反应发生率组间比较差异无统计学意义(P ＞ 0.05).结论 硫酸氢氯吡格雷联合那曲肝素钙治疗不稳定型心绞痛临床效果确切,安全性好,具有临床推广使用价值.%Objective To observe and investigate therapeutic effect and security of Clopidogrel Bisulfate combined with Nadroparin Calcium on unstable angina pectoris. Methods 196 patients with unstable angina pectoris from May 2007 to November 2010 in our hospital were chosen and randomly divided into two groups, of which, control group (98 patients) was given conventional treatment including resting in bed, controlling pressure, oral aspirin and lipid lowering drugs, nitrates intravenous and experimental group (98 patients) was given Clopidogrel Bisulfate combined with Nadroparin Calcium on the basis of conventional treatment. After treatment the therapeutic effects and adverse effects were assessed. Results The total effective rate of clinical symptoms and ECG improving of experimental group were significantly higher than control group (P < 0.05). The whole blood viscosity and plasma viscosity of control group and experimental group after treatment were significantly lower than the ones before treatment (P < 0.05) and the decrease level of experimental group were significantly higher than control group. There was no significant difference in the incidence of adverse effect between control group and experimental group (P > 0.05). Conclusion Clopidogrel Bisulfate combined with Nadroparin Calcium on unstable angina pectoris obtains excellent therapeutic effect and security.
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