Objective To study the clinical efficacy of Aluminum Phosphate Gel combined with Domperidone for treatment of patients with laryngopharngeal reflux disease. Methods 90 patients who was diagnosed as laryngopharngeal reflux disease were chosen and randomly divided into group A, B, C, each group for 30 cases. Group A was treated by Aluminum Phosphate Gel only, group B was treated by Domperidone only, group C was treated by Aluminum Phosphate Gel and Domperidone. After treatment, their clinical efficacies would be compared. Results After three months, the total effective rate of group A, B, C were 70.00%, 56.67%, 93.33%, compared with three groups, group C was the best, there were statistically significant differences among them. Conclusion The laryngopharngeal reflux disease is treated by the Aluminum Phosphate Gel and Domperidone, not only alleviates the gastric acid scathing the throat mucous membrane, but also farthest protects the countercurrent happening, consequently obtain essential efficacy.%目的 探讨磷酸铝凝胶联合多潘立酮治疗喉咽反流性疾病(LPRD)的临床效果.方法 选择已确诊为喉咽反流性疾病患者90例,随机分为A、B、C三组,每组各30例,A组给予磷酸铝凝胶治疗,B组给予多潘立酮治疗,C组给予磷酸铝凝胶与多潘立酮联合治疗,并观察三组用药后的临床疗效.结果 治疗3个月后,A、B、C三组的总有效率分别为70.00％、56.67％、93.33％,三组相比较,C组明显优于A组与B组,差异有统计学意义(P＜0.05).结论 联合应用磷酸铝凝胶与多潘立酮治疗喉咽反流性疾病,不但减轻了胃酸对咽喉黏膜的损伤,还最大限度地防止了反流的发生,从而达到根本的治疗效果.
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