Objective To explore the efficacy of early administration of bifidobacteria for infants and young children with allergic diseases in community. Methods After parental informed consent, 100 infants under 3 with a history of hypersen-sitivity were divided into two groups randomly: 50 infants in bifidobacterium group were given quadruple Bifidobacterium with breast milk or mixed feeding viable for 6 months. 50 infants in the control group were given breast milk or mixed feeding viable without any probiotics. After a six-months'-treatment, clinical allergy symptoms, IgG antibody positive rate and the level of IgE antibodies were detected and compared. Results The incidences of eczema, allergic diarrhea and rhinitis in the bifidobacterium group were significantly lower than that of bifidobacteria group; the differences of IgE antibodies and IgG antibody positive rate in two groups were all statistically significant (all P < 0.05). Conclusion In the community, administration of Bifidobacterium early to prevent allergic diseases among infants and young children has a certain effect, which can reduce the incidence of common allergic diseases of infants and young children.%目的 探讨社区早期口服双歧杆菌干预婴幼儿过敏性疾病的疗效.方法 选取本社区有过敏史的3岁以下的新生儿100例,经父母知情同意后,按随机的方法分为两组:双歧杆菌组50例,在母乳或混合喂养时添加双歧杆菌四联活菌,服6个月.对照组50例,在母乳或混合喂养时未添加任何微生态制剂.患儿在治疗6个月后来院随访过敏症状,检测并比较IgG抗体阳性率及IgE抗体水平.结果 湿疹、过敏性腹泻及鼻炎发病率在双歧杆菌组较对照组明显降低,双歧杆菌组较对照组IgG抗体阳性率及IgE抗体水平低,差异均有统计学意义(均P＜0.05).结论 在社区,针对婴幼儿过敏性疾病开展早期口服双歧杆菌干预有一定疗效,能降低婴幼儿常见过敏性疾病的发病率.
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