Objective: To explore the significance of testing myocardial enzyme and hs-CRP to HFMD's diagnosis and treatment on early stage in children's patients.Methods: Testing serum myocardial enzyme (α-HBDH, CK, CK-MB) and hs-CRP's level on early stage of 110 children's patients with HFMD, and randomly selecting 60 healthy children in the same period as control group.Results: The level of serum CK, CK-MB, hs-CRP and incidence of myocardial injury on HFMD's early stage were all significantly higher than those of the control group (P＜0.01), yet Level of a-HBDH were no significant difference compared with the control group (P＞0.05).The level of serum CK-MB, hs-CRP and incidence of myocardial injury in high risk factors group were all higher than general HFMD group (P＜0.05), yet Level of CK were no significant difference compared with the general HFMD group (P＞0.05).Conclusion: CK-MB has high specificity to predict myocardial injury, and hs-CRP is a sensitive indicator on early lesions, yet they are not sensitive and specific indicator together on HFMD's early stage, and testing serum myocardial enzyme combining with hs-CRP may provide scientific basis to HFMD's diagnosis and treatment on early stage.%目的:探讨超敏C-反应蛋白和心肌酶联合检测对手足口病患儿早期诊治的意义.方法:检测110例早期手足口病患儿血清α-羟丁酸脱氢酶(α-HBDH)、肌酸激酶(CK)、肌酸磷酸激酶同工酶MB(CK-MB)与超敏C-反应蛋白(hs-CRP)水平,并与同期60例健康儿童检测结果进行对照分析.结果:手足口病患儿病变早期CK、CK-MB、心肌损害发生率与hs-CRP均高于对照组(均P<0.01),而α-HBDH水平与对照组比较,差异无统计学意义(P>0.05).观察组中高危因素组患儿病变早期CK-MB、心肌损害发生率与hs-CRP均高于一般患儿组(均P<0.05),而CK水平与一般患儿组比较,差异无统计学意义(P>0.05).结论:CK-MB对判断心肌损害有高度特异性,hs-CRP为病变早期的敏感指标,但均非手足口病早期诊断的敏感特异性指标,联合检测心肌酶与ks-CRP可以为手足口病的早期诊治提供一定的科学依据.
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