Objective: To detemine the relationship between cough vaviant asthma ((CVA) in children and mycoplasma pnenumonia (MP) infection.Methods: 55 cases of CVA in children, 53 cases of bronchial asthma in children, 55 cases of MP infection (including pneumonia and bronchitis) in children, 43 cases of control group.The MP-IgM antibody level was detemined by particle agglutination method in (CVA children and the control group.Meantime total serum IgE level and the count of Eosinophics (EOS) detemined by ELISA methods and detected by venoud blood of anticoagulation, hematoxyliu eosin, with light microscope in CVA children, bronchial asthma in children and MP infection (including pneumonia and bronchitis) in children and the control group.Results: The positive rate of MP-IgM was 43.6％ in CVA children and was 18.6％ in the control group, there was a significant difference, the total MP-IgM was markedly higher in MP-IgM positive CVA children than in the MP-IgM of the control group (P＜0.05).The count of Eosinophics and total serum IgE level in CVA children, bronchial asthma in children and MP infection (including pneumonia and bronchitis) children were more than those of the control group (H=1 6.236, H=65.379, all P＜0.05).Moveover the coumt of Eosinophics and total serum IgE level in bronchial asthma group more than that of the C VA children (median=0.50, 0.44; median=180.5, 170.2), the count of Eosinophics and total serum IgE level in CVA in group greaten than mycoplasma pnenumonia MP infection group (median=0.44, 0.32; median=170.2, 159.10).Conclusion: There is a close relationship between CVA and MP infection in children.%目的:探讨小儿咳嗽变异性哮喘与肺炎支原体感染发病的关系.方法:收集小儿咳嗽变异性哮喘患儿55例、支气管哮喘患儿53例、肺炎支原体感染患儿(包括肺炎及支气管炎)55例及对照组患儿43例,采用颗粒凝集法检测小儿咳嗽变异性哮喘患儿及对照组患儿血清肺炎支原体IgM抗体(MP-IgM);同时采用ELISA方法和抗凝静脉血、伊红染色、光学显微镜检测小儿咳嗽变异性哮喘患儿、支气管哮喘患儿、肺炎支原体感染患儿和对照组患儿血清总IgE水平和计数嗜酸粒细胞.结果:小儿咳嗽变异性哮喘患儿MP-IgM 阳性率为43.6%,显著高于对照组患儿MP-IgM 阳性率(18.6%)(P<0.05) ;小儿咳嗽变异性哮喘患儿、支气管哮喘患儿、肺炎支原体感染患儿外周血计数嗜酸粒细胞及血清总IgE水平明显高于对照组患儿(H=16.236、H=65.379,均P<0.05),且支气管哮喘患儿血嗜酸粒细胞计数及血清总IgE大于小儿咳嗽变异性哮喘患儿(median=0.50、0.44;median=180.5、170.2),小儿咳嗽变异性哮喘患儿血嗜酸性粒细胞计数及血清总IgE大于肺炎支原体感染患儿(median=0.44、0.32;median=170.2、159.10).结论:小儿咳嗽变异性哮喘与肺炎支原体感染发病密切相关.
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