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首页> 中文期刊> 《中国医药导报》 >甘露聚糖肽注射液对进展期胃癌化疗免疫抑制的临床研究

甘露聚糖肽注射液对进展期胃癌化疗免疫抑制的临床研究

         
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摘要

Objective: To evaluate the efficacy of immunosuppression of Mannatide in the treatment of advanced gastric carcinoma. Methods: 68 pathological specimens of advanced gastric cancer patients were enrolled in two groups randomly. 30 patients in control group were given FOLFOX4 chemotherapy. While 38 cases in treatment group were given Mannatide Injection on basis of control group. CD3+CD8+T cell, CD3+CD4+T cell, NK cell and CD4+CD25++Treg in peripheral blood were determined by flow cytometer before and after treatment. Response rate was assessed after two treatment cycle. Results: In all 68 patients, CR rate of treatment group was higher than control group (13.15％ vs 0％, X2=4.261, P=0.048), while there is no difference in other endpoints of short-term therapeutic effects. CD4+CD25++Treg of treatment group decreased significantly (P=0.008), and the proportion of CD4+CD25++Treg was also lower than that of control group after treatment (P=0.013). And the level of CD3+CD4+T cell, NK cell were also superior to control group after treatment (P=0.043, 0.036). The life quality score of treatment group was also higher than control group (P＜0.05). Conclusion: Mannatide can improve CR rate of advanced gastric carcinoma patients, it has no advantage in short-term therapeutic effects, but it can improve immune function.%目的:评价甘露聚糖肽改善进展期胃癌免疫抑制的疗效.方法:入组68例晚期胃癌患者分为FOLFOX4方案组(对照组30例)与甘露聚糖肽联合FOLFOX4方案组(治疗组38例),于化疗前后检测两组CD3+CD8+T细胞亚群、CD3+CD4+T细胞亚群、NK细胞和CD4+CD25++调节性T细胞(CD4+CD25++Treg),并于化疗2个周期后评估化疗疗效.结果:治疗组完全缓解率优于对照组(13.15% vs 0%,χ2=4.261,P=0.048),其他近期疗效指标差异无统计学意义.治疗组CD4+CD25++Treg治疗前后下降明显(P=0.008),且治疗后显著低于对照组(P=0.013),治疗组治疗后CD3+CD4+T细胞、NK细胞水平则明显高于对照组治疗后(P=0.43、0.036).同时治疗组的生活质量评分亦高于对照组,差异有统计学意义(P＜0.05).结论:晚期胃癌患者化疗中,加用甘露聚糖肽注射液虽能提高化疗完全缓解率,但未见提高疾病控制的近期疗效,但可以显著改善患者的免疫抑制状态.

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  • 来源
    《中国医药导报》 |2011年第27期|67-69|共3页
  • 作者

    王刚; 胡冰; 季楚舒; 胡长路; 江丰收; 何义富; 王勇; 孙玉蓓;

  • 作者单位

    安徽医科大学附属安徽省立医院肿瘤内科,安徽合肥,230000;

    安徽医科大学附属安徽省立医院肿瘤内科,安徽合肥,230000;

    安徽医科大学附属安徽省立医院肿瘤内科,安徽合肥,230000;

    安徽医科大学附属安徽省立医院肿瘤内科,安徽合肥,230000;

    安徽医科大学附属安徽省立医院肿瘤内科,安徽合肥,230000;

    安徽医科大学附属安徽省立医院肿瘤内科,安徽合肥,230000;

    安徽医科大学附属安徽省立医院肿瘤内科,安徽合肥,230000;

    安徽医科大学附属安徽省立医院肿瘤内科,安徽合肥,230000;

  • 原文格式 PDF
  • 正文语种 chi
  • 中图分类 胃肿瘤;
  • 关键词

    晚期胃癌; 甘露聚糖肽; 化疗; 免疫抑制;

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