目的：探索分析动静脉联合尿激酶溶栓结合动脉成形术治疗大血管病变引起急性脑梗死的临床效果和安全性。方法选择我院收治的大血管病变引起急性脑梗死患者作为研究对象并进行分组治疗，研究组均应用动静脉联合尿激酶溶栓结合动脉成形术进行治疗，对照组均予应用静脉溶栓进行治疗。将两组患者的临床疗效及其安全性进行对比。结果两组研究对象治疗前神经功能缺损症状（NIHSS）评分以及日常生活活动能力（ADL）评分不存在显著性差异（P＞0.05）；研究组治疗后NIHSS评分明显低于对照组，但该组患者的ADL评分则明显高于对照组（P＜0.05）。研究组治疗总有效率为91.11%，明显超过对照组的73.33%（P＜0.05）。两组患者均发生一定比例的消化道出血，皮下出血以及发热等不良反应，均经对症处理后有效控制。研究组8例（8.89%），对照组9例（10.00%），差异无统计学意义（P＞0.05）。结论应用动静脉联合尿激酶溶栓结合动脉成形术治疗大血管病变引起急性脑梗死，可以产生显著的效果，安全性高，有利于患者预后，具有极大的推广应用价值。%ObjectiveTo explore and analyze clinical curative effect and safety of combination of artery and vein,urokinase thrombolysis and arterioplasty in treatment of acute cerebral infarction caused by large vascular disease.MethodsPatients with acute cerebral infarction caused by large vascular disease who were admitted to our hospital were selected as research objects and they were allocated to the research group and the control group to receive treatment.The research group was received treatment of combination of artery and vein,urokinase thrombolysis and arterioplasty while th control group was received treatment of intravenous thrombolysis.Clinical curative effect and safety of two groups were compared.Results National institutes of health stroke scale(NIHSS)score and activities of daily living(ADL)score before treatment of patients in two groups had no significant differences(P>0.05).NIHSS score after treatment of the research group was significantly lower than that of the control group while the ADL score of the research group was significantly higher than that of the control group(P<0.05).Total effective rate of treatment of the research group was 91.11% which was significantly higher than that of the control group 73.33%(P<0.05).Certain proportion of patients in two groups all had adverse reactions including gastrointestinal hemorrhage,subcutaneous hemorrhage,fever and so on. In addition,they were under control after expectant treatment. There were 8 patients(8.89%)in the research group and 9 patients(10.00%)in the control group.The difference was not significant(P>0.05).Conclusion Combination of artery and vein, urokinase thrombolysis and arterioplasty in treatment of acute cerebral infarction caused by large vascular disease has a significant effect and high safety which is helpful to prognosis of patients and worthy of promotion and application.
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