目的：分析右美托咪定对全麻下行脑血管瘤夹闭术患者脑功能的保护作用。方法将我院2013年3月~2015年3月收治的80例接受全麻下脑血管瘤夹闭术治疗的患者随机分为对照组与观察组，各40例。观察组静脉给予右美托咪定作脑保护处理，对照组则给予生理盐水，比较两组患者脑功能的保护效果。结果麻醉后、手术开始时、供瘤动脉阻断时、阻断动脉瘤时、恢复供瘤动脉及术毕观察组心率及平均动脉压的变化与对照组相比差异有统计学意义（P＜0.05）；术后12h及24h，观察组血清NSE水平分别为（16.7±3.8）ng/mL、（23.5±4.5）ng/mL，均明显低于对照组（P＜0.05）。结论对全麻下行脑血管瘤夹闭术的颅内动脉瘤患者应用右美托咪定方案，可稳定患者循环系统及血流动力学，有效保护患者脑组织，值得推广。%Objective To analyze the protective effect of predetermine on brain function of patients with clipping of cerebral aneurysm under general anesthesia.Methods 80 patients admitted into the hospital for clipping of cerebral aneurysm under general anesthesia from March 2013 to March 2015 and were randomly divided into the control group and the observation group of two groups with 40 cases in each. The observation group was given intravenous injection of predetermine for cerebral protection while the control group was given saline. The protective effects of brain function in the two groups were compared.ResultsAfter anesthesia, at the beginning of the operation, when tumor-supplied arteries were blocked, when aneurysm was blocked, when tumor-supplied arteries recovered and at the end of operation, the heart rate and changes of mean arterial pressure of the observation group, compared with the control group, the difference was statistically significant(P<0.05); 12h and 24h after operation, serum NSE levels of the observation group respectively were (16.7±3.8)ng/mL and (23.5±4.5)ng/mL which were significantly lower than those of the control group(P<0.05).Conclusion For anesthesia cerebral aneurysms clipping of contractile aneurysm patients given predetermine program, stable hydrodynamics in patients with circulatory system and effectively protect brain tissue of patients, should be promoted.
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