Objective To study clinical effect of Smecta in treatment of colitis, diarrhea and the drug effect mechanism analysis, provide a reliable basis for the clinical. Methods In our hospital 162 cases of ulcerative colitis patients with diarrhea, which according to the drawing method is divided into the observation group and the control group. The control group were treated with oral sulfasalazine treatment, patients in acute period of 1g/time, four times a day, to be in remission after 0.5g/times, seriously ill patients sulfasalazine suppositories can be inserted into the anus, once a day;patients in the observation group was treated with Smecta treatment, three times a day, a bag three, seriously ill patients given a two bag, pour in 100mL water retention enema, once a day. And the incidence of adverse reactions compared the clinical efficacy of two groups of patients. Results The group of significant efficiency, efficiency, less efficient, total effective rate was 41.97%, 49.38%, 8.65%, the control group markedly effective, effective, less efficient, total effective rate was 37.04%, 43.21%, 19.75%, 80.25%, compared two groups of patients with significant differences (P < 0.05). The observation group and the control group took the adverse reaction rate were 4.94% and 11.11%, it showed significant difference (P <0.05). Conclusion Smecta treatment has a significant clinical effect of diarrhea and ulcerative colitis, and low incidence rate of adverse reaction, with a higher patient satisfaction, suitable for wide popularization and clinical application.%目的：研究思密达治疗结肠炎腹泻的临床效果，并对其药物作用机制进行分析，为临床提供可靠的参考依据。方法选取我院收治的162例溃疡性结肠炎腹泻患者，将其按照抽签方法分为观察组和对照组，对照组患者给予口服柳氮磺吡啶片进行治疗，急性期患者1g/次，4次/d，待病情缓解后给予0.5g/次，病情严重的患者可将柳氮磺吡啶栓塞入肛门，1次/d；观察组患者则给予思密达进行治疗，3次/d，1次3袋，病情严重的患者给予1次2袋，倒入100mL温水中保留灌肠，1次/d。对比两组患者的临床治疗效果及不良反应发生情况。结果观察组显效率、有效率、无效率、总有效率分别为41.97%、49.38%、8.65%，对照组显效率、有效率、无效率、总有效率分别为37.04%、43.21%、19.75%、80.25%，两组患者比较差异有统计学意义（P＜0.05）。观察组和对照组不良反应发生率分别为4.94%和11.11%，比较差异有统计学意义（P＜0.05）。结论思密达治疗溃疡性结肠炎腹泻具有显著的临床效果，且不良反应发生率较低，患者满意度较高，适合在临床广泛推广及应用。
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