Objective To get the genetic information and forensic parameters for the STR locus of D1S1656 in Hu'nan Chinese Han population . Methods All 451 unrelated individuals of Hu'nan Chinese Han population were selected to analyze genetic polymorphisms by using the Powerplex 21 system kit. The deviation of allele frequencies from Hardy-weinberg equilibrium was tested and the forensic parameters were counted by software. Results The marker of D1S1656 showed no significant deviation from Hardy-weinberg expectations, and 16 alleles were found with Power of Discrimination was 0.954 and Power of Exclusion 0.667. Conclusion The STR marker of D1S1656 present rich polymorphisms in Hu'nan Chinese Han population and could provide effective application in forensic field.%目的：为了获得湖南汉族人群D1S1656基因座遗传多态性信息及其法医学参数。方法采用Powerplex 21 system试剂盒检测湖南汉族无关个体451例，对D1S1656基因座进行Hardy-weinberg平衡检验，并计算其法医学参数。结果 D1S1656基因座符合Hardy-weinberg平衡(P>0.05)，共发现16个等位基因，个体识别力(Power of Discrimination，DP)0.954，非父排除率(Power of Exclusion，PE)0.667。结论 D1S1656基因座在湖南汉族人群中具有良好多态性，有法庭科学应用价值。
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