肾素－血管紧张素系统( RAS）被认为参与了非酒精性脂肪性肝病（NAFLD）的发生、发展，阻断RAS的激活是治疗NAFLD的途径之一。血管紧张素－（1－7）[ Ang－(1－7)]是RAS的新成员，与血管紧张素Ⅱ（AngⅡ）相比，被认为可改善胰岛素抵抗、肝纤维化、脂质沉积及门静脉高压等。该文就Ang－(1－7)在NAFLD发病机制中的作用及其治疗前景进行综述，以探讨Ang－(1－7)能否成为治疗NAFLD的新方向。%The renin-angiotensin system ( RAS ) is considered to play an important role in the development and progression of nonalco-holic fatty liver disease ( NAFLD ) . The blocking of RAS activation is one of the pathways for treating NAFLD. Angiotensin-( 1-7 ) [ Ang-( 1-7 ) ] is recognized as one of the RAS new members. It is considered that compared with angiotensin Ⅱ ( Ang Ⅱ) , Ang-( 1-7 ) could ameliorate insulin resistance ( IR ) , hepatic fibrosis, lipid accumulation and portal hypertension, etc. This paper reviews the role of Ang-( 1-7 ) in the pathogensis of NAFLD and its therapeutical prospect in order to explore whether Ang-( 1-7 ) could become a new direction for treating NAFLD.
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