Objective To compare the clinical effects of series of quinolone antibacterials in treating community acquired pneumonia (CAP),and to perform the cost-effectiveness( C/ E) analysis by adopting the pharmacoeconomics principles. Methods Totally 160 patients with CAP were selected and divided into the group A,B,C and D according to the admission sequence,40 cases in each group. The group A was given Levoflozacin Lactate and Sodium Chloride Injection,the group B was given Lomeflozacin Hydrochloride and Sodium Chloride Injection,the group C was given Gatiflozacin and Sodium Chloride Injection and the group D was given with Moz-iflozacin Hydrochloride and Sodium Chloride Injection;the course of treatment in 4 groups was 7 d. The cost-effectiveness analysis was performed after 7 d the treatments. Results The total effective rate and the incidence of adverse reactions were 82. 50% and 15. 00%in the group A,85. 00% and 12. 50% in the group B,95. 00% and 15. 00% in the group C,and 95. 00% and 10. 00% in the group D, respectively,the differences among 4 groups had no statistical significance( P > 0. 05). C/ E in the group A was the lowest(4. 68)andΔC/ΔE in the group C was the lowest(10. 75). C/ / E in the group A was the lowest(4. 22)and ΔC/ /ΔE in the group C was the lowest(9. 68). Conclusion Levoflozacin Injection in the treatment of CAP has the lowest C/ E and higher pharmacoeconomics value;while gatiflozacin has the lowest ΔC/ΔE,and consequently is the best replacement.%目的：对比系列喹诺酮类抗菌药物治疗社区获得性肺炎（ CAP ）的临床疗效，并应用药物经济学原理进行成本－效果分析。方法选择CAP患者160例，按入院顺序分为A组、B组、C组、D组，各40例。A组给予乳酸左氧氟沙星氯化钠注射液，B组给予盐酸洛美沙星氯化钠注射液，C组给予加替沙星氯化钠注射液，D组给予盐酸莫西沙星氯化钠注射液，疗程均为7d。结果 A组总有效率为82.50%，不良反应发生率为15.00%；B组总有效率为85.00%，不良反应发生率为12.50%；C组总有效率为95.00%，不良反应发生率为15.00%；D组总有效率为95.00%，不良反应发生率为10.00%。4组患者总有效率及不良反应发生率相比，差异无统计学意义（ P＞0.05）。A组 C/ E最低，为4.68；C组ΔC/ΔE最低，为10.75。A组 C// E最低，为4.22；C组ΔC//ΔE最低，为9.68。结论左氧氟沙星注射液治疗CAP的 C/ E最低，具有更高的药物经济学价值；加替沙星ΔC/ΔE最低，是最佳的替代选择。
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