OBJECTIVE: To investigate the clinical effect of clinical pharmacists intervening in perioperative prophylactic application of antibacterials for breast cancer patients. METHODS: The clinical pharmacists assessed the perioperative prophylactic application of antibacterials for breast cancer surgery regularly, including modified radical mastectomy, mastectomy and breast conserving surgery, as well as the incidence of surgical site infection (SSI). The intervention measures of rational use of antiobacterials were formulated. Medical records of patients underwent surgery were collected from breast diagnosis and treatment center of our hospital. 85 medical records were collected during Aug. 2010 as pre-intervention group while 131 medical records during Aug. 2011 as intervention group. Control study was conducted before and after intervention. RESULTS: After intervention, the proportion of perioperative prophylactic application of antibacterials decreased from 94.12% to 19.85%; the proportion of the application duration of antibacterials ( ≤24 hours) increased from 18.75% to 69.23% ; the incidence of SSI was 3.82% after intervention and 3.53% before intervention; there was no statistical significance. CONCLUSION: It is effective and feasible that clinical pharmacists intervene in perioperative prophylactic application of antibacterials, and the incidence of SSI keeps stable after perioperative prophylactic application of antibacterials for breast cancer type I incision is reduced.%目的:评价临床药师干预乳腺癌患者围术期预防用抗菌药物的效果.方法:通过临床药师定期评估乳腺癌手术(乳腺癌改良根治术、乳房切除术、乳腺癌保乳手术)患者围术期预防用抗菌药物情况与手术部位感染率,制订抗菌药物合理应用干预措施,并抽取我院乳腺诊疗中心接受手术治疗的Ⅰ类切口手术患者病历,2010年8月(干预前组)85份,2011年8月(干预后组)131份,进行干预前、后对照研究.结果:经临床药师干预,患者围术期预防用药比例由94.12％下降至19.85％,干预后围术期预防用药时间不超过24 h者所占比例由18.75％增加到69.23％；干预后手术部位感染率为3.82％,干预前为3.53％,2组患者比较差异无统计学意义(P＞0.05).结论:临床药师干预抗菌药物围术期应用有效可行,乳腺癌Ⅰ类切口降低围术期抗菌药物应用比例不会增加手术部位感染率.
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