目的:观察维生素E(VE)对胃黏膜损伤模型小鼠的保护作用.方法:取小鼠50只随机均分为正常对照组、模型组、西咪替丁(25 mg·kg-1)组和VE低、高剂量(25、50 mg·kg-1)组,灌胃给予相应药物30 min后,后4组灌胃给予吲哚美辛25 mg·kg-1,4h后处死小鼠,检测各组小鼠胃黏膜损伤程度及血清中超氧化物歧化酶(SOD)活性、丙二醛(MDA)含量.结果:与正常对照组比较,模型组小鼠胃黏膜损伤指数和SOD活性、MDA含量均明显升高(P＜0.01)；与模型组比较,西咪替丁组和VE低、高剂量组小鼠胃黏膜损伤指数和SOD活性、MDA含量均明显降低(P＜0.01)；与西咪替丁组比较,VE高剂量组小鼠胃黏膜损伤指数和SOD活性均明显降低(P＜0.01).结论:VE可能通过抗氧化、清除氧自由基和抑制脂质过氧化过程发挥预防胃黏膜损伤的作用,且VE高剂量(50 mg·kg-1)组对胃黏膜损伤的保护作用强于西咪替丁(25 mg·kg-1)组.%OBJECTIVE: To observe protective effect of vitamin E (VE) on gastric mucosal injury model mice. METHODS: 50 mice were randomly divided into normal control group, model group, cimetidine group (25 mg·kg-1) and VE low-dose and high dose groups (25, 50 mg·kg-1). The latter 4 groups were given indometacin 25 mg·kg-1 intragastircally 30 min after intragas-trical administration. Those mice were sacrificed 4 h later. Gastric mucosal injury, SOD actirity and MDA content were determined. RESULTS: Compared with normal control group, gastric mucosal injury index, SOD activity and MDA content of model group increased significantly (P＜0.01). Compared with model group, gastric mucosal injury index, SOD activity and MDA content of cimetidine group and VE groups decreased significantly (P＜0.01). Compared with cimetidine group, gastric mucosal injury index and SOD activity of VE high-dose group decreased significantly (P＜0.01). CONCLUSION: VE can prevent gastric mucosal injury by antioxidation and scavenging oxygen free radicals, and protective effect of VE high-dose group (50 mg·kg-1) on gastric mucosal injury is better than cimetidine group (25 mg·kg-1).
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