Objective To investigate the incompatibility between cefamandole nafate for injection and omeprazole sodium for injection.Methods High performance liquid chromatography (HPLC) was applied to detect changes of external appearance, relative amount and pH of cefamandole nafate and omeprazole sodium in different time points during 6 h under 4, 25, and 30℃.Results After 6 h under indoor temperature (25 and 30℃), the solutions had obvious changes in external appearance, clarity, and pH. Contents of cefamandole nafate and omeprazole sodium were remarkably decreased.Conclusion Cefamandole nafate for injection is incompatible with omeprazole sodium for injection, and they should be applied separately.%目的：探讨注射用头孢孟多酯钠与注射用奥美拉唑钠的配伍禁忌。方法高效液相色谱法(HPLC)法测定头孢孟多酯钠、奥美拉唑钠配伍液在4、25、30℃环境下放置6 h内不同时间点外观、相对含量及pH值的变化。结果在室温(25、30℃)条件6 h下，配伍液外观、澄明度及pH值发生明显变化，且头孢孟多酯钠、奥美拉唑钠含量明显降低。结论注射用头孢孟多酯钠与注射用奥美拉唑钠存在配伍禁忌，应间隔使用。
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