目的 探讨乳腺癌患者中PKM2基因表达水平,并分析PKM2基因表达与乳腺癌预后的关系.方法 采用生物信息学方法 ,利用互联网平台和开放性的基于基因芯片检测的基因表达数据库,比较PKM2基因在乳腺癌组织与乳腺正常组织中的表达差异,分析PKM2表达水平与乳腺癌预后的关系.结果 PKM2在乳腺癌中的表达水平明显高于正常乳腺组织(P<0.05).PKM2表达与乳腺癌患者预后密切相关,PKM2高表达者的疾病特异性生存率显著低于低表达者(HR=1.897,95%CI:1.117~3.221,P<0.05),PKM2高表达者较PKM2低表达者具有较短的无病生存时间(HR=1.605,95%CI:1.050~2.451,P=0.029)和无复发生存时间(HR=7.377,95%CI:1.906~28.548,P=0.004).结论 PKM2基因在乳腺癌组织中呈高表达,其表达水平对预测乳腺癌患者的预后具有重要意义.%Objective To explore the expression of PKM2 gene in breast cancer patients, and investigate the impact of PKM2 gene expression on prognosis of breast cancer. Methods Bioinformatics and free open gene chip data-set provided by Oncomine database and gene expression omnibus ( GEO) database were used to analyze the expression of PKM2 gene in breast cancer patients. The relationship between PKM2 gene and prognosis of breast cancer was analyzed depending on PKM2 expression level. Results Ex-pression level of PKM2 gene in breast cancer was significantly higher than that in normal breast tissue ( P<0. 05) . The disease-specific survival rate of breast cancer patients with high-expression of PKM2 gene were significantly lower than those with low-expression of PKM2 gene(HR=1. 897,95%CI:1. 117-3. 221, P<0. 05).The disease-free survival time and the recurrence-free survival time of breast cancer patients with high-expression of PKM2 gene was significantly shorter than those with low-expression of PKM2 gene( HR=1. 605, 95%CI:1. 050-2. 451, P=0. 029; HR=7. 377, 95%CI:1. 906-28. 548, P=0. 004). Conclusion PKM2 gene is high ex-pression in breast cancer, and the expression level of PKM2 has important significance in predicting the prognosis of breast cancer.
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