Objective To investigate the clinicopathological features of anaplastic lymphoma kinase( ALK) protein positive expression in non⁃small cell lung cancer(NSCLC)patients. Methods The expression of ALK protein was detected in 141 cases of NSCLC by immunohistochemistry( IHC) . The data of clinicopathological features of patients with ALK positive expression was collected and analyzed. Results The positive rate of ALK protein in NSCLC was 9�2%(13/141).The positive rate was closely associated with age and epidermal growth factor receptor( EGFR) mutation( P<0�05) , but not correlated with sex, smoking, drinking, histopathology, primary site, lymph node metastasis and the expression of thyroid transcription factor⁃1(P>0�05). Conclusion Young age (≤57 years) , EGFR negative patients with NSCLC are recommended the detection of ALK.%目的：探讨非小细胞肺癌（ NSCLC）中伴渐变性淋巴瘤激酶（ ALK）蛋白阳性表达患者的临床病理特征。方法采用免疫组织化学技术检测141例NSCLC患者中ALK蛋白的表达情况，收集与分析伴ALK阳性表达患者的临床病理特征。结果免疫组织化学检测显示，NSCLC患者中ALK蛋白的阳性表达率为9�2％（13／141）。 ALK阳性表达率在年龄、是否有表皮生长因子受体（ EGFR）突变之间的差异均有统计学意义（ P＜0�05），而在性别、是否吸烟、是否饮酒、病理分型、原发部位、是否有甲状腺转录因子⁃1表达及有无淋巴结转移之间的差异无统计学意义（ P＞0�05）。结论年轻（年龄≤57岁）、EGFR阴性的NSCLC患者是ALK突变的高发人群，建议此类患者进行ALK检测。
展开▼
