Objective To evaluate the association between cyclooxygenase-2 ( COX-2) gene polymorphisms and digestive system tumor risk. Methods All studies published up to February 2013 on the association between-765G>C polymorphism of COX-2 and digestive system tumor susceptibility were identified by searching in PubMed, EMBASE and Web of Science databases. The corre-lated index was extracted for aggregate analysis in Stata/SE 12.0. Results A total of 11 083 patients and 16 856 controls from 40 pa-pers were included in the meta-analysis. Overall analysis showed that the C allele contrast model and the CG, CC/CG genotype were significantly associated with the increased digestive system tumor risk compared with the G allele contrast model and the GG genotype. Stratification analysis by ethnicity and tumor position showed that the C allele contrast model and the CG, CC/CG genotypes were sig-nificantly associated with the increased risk in Asian descendents and digestive tract tumors. No statistically significant associations were detected in Caucasian and digestive gland tumor subgroups. Stratification analysis by source of control, the C allele contrast model and the CG genotypes were significantly associated with the increased risk in the population-based ( PB) subgroup. No statistically signifi-cant associations were detected in hospital-based ( HB) subgroup. Conclusion The COX-2-765G>C polymorphism is significantly as-sociated with digestive system tumor susceptibility, especially among Asian populations.%目的：系统评价环氧合酶-2（ COX-2）-765G＞C位点基因多态性与消化系统肿瘤易感性的关系。方法计算机检索PubMed、EMBASE、Web of Science数据库的文献，收集2013年2月前所有关于COX-2基因多态性与消化系统肿瘤易感性的研究。采用Stata/SE 12�0软件进行Meta分析。结果共检索出84篇相关文献，其中40篇可纳入研究，共计11083例消化系统肿瘤患者和16856例对照人群。总研究人群分析显示，与G等位基因、GG基因型相比，COX-2-765G＞C 位点C等位基因及CG、CC/CG基因型显著增加了消化系统肿瘤的罹患风险。按人种、肿瘤发生部位的分层分析显示， C等位基因及CG、CC/CG基因型显著增加了亚洲人种消化系统肿瘤及总研究人群消化道肿瘤的罹患风险，未观察到COX-2-765G＞C基因多态性与高加索人种消化系统肿瘤及总研究人群消化系统肿瘤的易感性相关。按对照组来源分层分析显示，C等位基因及GC基因型显著增加了基于人群（ PB）对照来源的亚组消化系统肿瘤的罹患风险，未观察到COX-2-765G＞C基因多态性与基于医院（ HB）对照来源的亚组消化系统肿瘤的易感性相关。结论 COX-2-765G＞C 基因多态性显著增加亚洲人种的消化系统肿瘤罹患风险。
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