Objective To observe the effect of traditional Chinese medicine (TCM) and acupuncture in improving quality of life( QOL) of elderly patients with advanced non-small cell lung cancer (NSCLC). Methods A total of 199 patienls of stage I or IV NSCLC were randomly assigned into two groups, 100 in TCM & acupuncture group and 99 in control group. The control group was divided in two groups according to PS scores(PS≤ 2 or PS =3), with who PS≤ 2 received chemotherapy(n =51) and PS = 3 received best support care (re = 48). Functional assessment of cancer therapy-lung (FACT-L) was used to evaluate the quality of life between two groups. Results The QOL was improved significantly in TCM & acupuncture group, and decreased significantly in BSC group. In chemotherapy group, the change of QOL was improved at first and decreased at last. Conclusion TCM & acupuncture can improve the QOL of elderly patients with advanced non-small cell lung cancer.%目的 观察针药结合对Ⅲ、Ⅳ期老年非小细胞肺癌(NSCLC)患者生存质量的影响.方法 采用随机、对照方法将199例入组病例按1∶1分为治疗组100例(针药结合组)和对照组99例(西医治疗组),对照组再分为化疗组51例(PS≤2)和最佳支持组48例(PS=3).采用肺癌治疗功能评价表(第4版)中文版对治疗组和对照组在治疗过程中的生存质量变化进行评价分析.结果 治疗组治疗后(d42、d63、d84)生存质量积分与治疗前相比均有上升,差异有统计学意义(P＜0.05)；化疗组因化疗药物毒副作用影响,表现为先升后降；最佳支持组d63、d84两次测量积分与治疗前相比均有下降,差异有统计学意义(P＜0.05).结论 针药结合的中医药综合疗法可望提高中晚期老年NSCLC患者的生存质量.
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