Pemetrexed versus docetaxel single agent chemotherapy in chemotherapy-naive elderly patients with advanced non-small cell lung cancer

机译：培美曲塞与多西他赛单药化疗在未接受化疗的老年晚期非小细胞肺癌患者中的作用

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To compare the efficacy and toxicity of pemetrexed and docetaxel single agent chemotherapy in chemotherapy-naive elderly patients with advanced non-small cell lung cancer, the clinical data of 54 elderly patients were retrospectively analyzed. 19 patients accepted pemetrexed single agent chemotherapy and 35 patients accepted docetaxel single agent chemotherapy. The median OS of pemetrexed group and docetaxel group was 16.10 months and 18.90 months respectively. In the pemetrexed group, DCR was 73.68%. In the docetaxel group, DCR was 71.43%. No statistically significant difference was found. The toxicity of pemetrexed single agent chemotherapy was lower in terms of hematologic and alopecia. In the subgroup analysis, the OS and DCR of non-squamous non-small cell lung cancer in pemetrexed group were longer and higher than those of the docetaxel group. Elderly patients with good Performance Status and good body condition can tolerate the pemetrexed and docetaxel single agent chemotherapy. The pemetrexed single agent chemotherapy was recommended for lower toxicity, especially in non-squamous patients.

机译：为了比较培美曲塞和多西他赛单药化疗对未接受化疗的老年晚期非小细胞肺癌患者的疗效和毒性，回顾性分析了54例老年患者的临床资料。 19例接受培美曲塞单药化疗，35例接受多西他赛单药化疗。培美曲塞组和多西他赛组的中位OS分别为16.10个月和18.90个月。在培美曲塞组中，DCR为73.68％。在多西他赛组中，DCR为71.43％。没有发现统计学上的显着差异。在血液学和脱发方面，培美曲塞单药化疗的毒性较低。在亚组分析中，培美曲塞组的非鳞状非小细胞肺癌的OS和DCR比多西他赛组的更长，更高。表现状态良好且身体状况良好的老年患者可以耐受培美曲塞和多西他赛单药化疗。推荐使用培美曲塞单药化疗以降低毒性，特别是对于非鳞状患者。

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《2011 International Conference on Human Health and Biomedical Engineering》|2011年|p.1331-1334|共4页
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Hua Xin; Zhenguo Han; Haibo Huang;
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中图分类生物医学工程;
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carcinoma; chemotherapy; docetaxel; elderly; non-small-cell lung cancer; pemetrexed;

机译：癌;化学疗法;多西他赛;老年人;非小细胞肺癌;培美曲塞;

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1. Prognostic factors in non-small cell lung cancer patients who are recommended to receive single-agent chemotherapy (docetaxel or pemetrexed) as a second- or third-line chemotherapy: in the era of oncogenic drivers and molecular-targeted agents [J] . Shukuya Takehito, Ko Ryo, Mori Keita, Cancer chemotherapy and pharmacology. . 2015,第4期

机译：非致癌小细胞肺癌患者的预后因素：在致癌驱动因素和分子靶向药物时代，建议接受单药化疗（多西他赛或培美曲塞）作为二线或三线化疗
2. Randomized phase III trial comparing single-agent paclitaxel Poliglumex (CT-2103, PPX) with single-agent gemcitabine or vinorelbine for the treatment of PS 2 patients with chemotherapy-naive advanced non-small cell lung cancer. [J] . OBrien ME, Socinski MA, Popovich AY, Journal of thoracic oncology: official publication of the International Association for the Study of Lung Cancer . 2008,第7期

机译：比较单药紫杉醇Poliglumex（CT-2103，PPX）与单药吉西他滨或长春瑞滨治疗PS 2初治性晚期非小细胞肺癌患者的随机III期试验。
3. Efficacy of Platinum-Based Doublet Chemotherapy Versus Single-Agent Chemotherapy as Second-Line Treatment in Elderly Patients with Advanced Non-Small Cell Lung Cancer [J] . Yan X. T., Wang H. J., Li P., Journal of the American Geriatrics Society . 2019,第Suppla4期

机译：基于铂的双层化疗与单孕中化疗的疗效，作为老年晚期非小细胞肺癌患者的二线治疗
4. Pemetrexed versus docetaxel single agent chemotherapy in chemotherapy-naive elderly patients with advanced non-small cell lung cancer [C] . Hua Xin, Zhenguo Han, Haibo Huang International Conference on Human Health and Biomedical Engineering . 2011

机译：聚乙烯型多发性药物化疗在化疗 - 天真老年患者晚期非小细胞肺癌患者
5. Predictors of changes in health-related quality of life during chemotherapy in an advanced non-small cell lung cancer patient population [D] . Shallwani, Shirin Mehdi 2010

机译：非小细胞肺癌晚期患者化疗期间健康相关生活质量变化的预测因子
6. Triplet chemotherapy combination with cisplatin gemcitabine and docetaxel in patients with chemotherapy-naive advanced non-small cell lung cancer [O] . FARUK TAS, FATMA SEN, NESE GUNEY, -1

机译：初治晚期非小细胞肺癌三联化疗联合顺铂吉西他滨和多西他赛的患者
7. Single-Agent Pemetrexed or Sequential Pemetrexed/Gemcitabine as Front-Line Treatment of Advanced Non-small Cell Lung Cancer in Elderly Patients or Patients Ineligible for Platinum-Based Chemotherapy: A Multicenter, Randomized, Phase II Trial [O] . Gridelli Cesare, Kaukel Eckhard, Gregorc Vanessa, 2007

机译：单药培美曲塞或序贯培美曲塞/吉西他滨作为老年患者或不适合铂类化疗的晚期非小细胞肺癌的一线治疗：多中心，随机，II期试验

Pemetrexed versus docetaxel single agent chemotherapy in chemotherapy-naive elderly patients with advanced non-small cell lung cancer

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