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PREDICTING RESPONSE TO PEMETREXED CHEMOTHERAPY IN NON-SMALL CELL LUNG CANCER (NSCLC) WITH BASELINE COMPUTED TOMOGRAPHY (CT) SHAPE AND TEXTURE FEATURES
PREDICTING RESPONSE TO PEMETREXED CHEMOTHERAPY IN NON-SMALL CELL LUNG CANCER (NSCLC) WITH BASELINE COMPUTED TOMOGRAPHY (CT) SHAPE AND TEXTURE FEATURES
Methods, apparatus, and other embodiments predict response to pemetrexed based chemotherapy. One example apparatus includes an image acquisition circuit that acquires a radiological image of a region of tissue demonstrating NSCLC that includes a region of interest (ROI) defining a tumoral volume, a peritumoral volume definition circuit that defines a peritumoral volume based on the boundary of the ROI and a distance, a feature extraction circuit that extracts a set of discriminative tumoral features from the tumoral volume, and a set of discriminative peritumoral features from the peritumoral volume, and a classification circuit that classifies the ROI as a responder or a non-responder using a machine learning classifier based, at least in part, on the set of discriminative tumoral features and the set of discriminative peritumoral features.
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