Objective To investigate the expression of Gli-1 protein in non-small cell lung cancer(NSCLC) , and discuss the relationship between the expression and tumor's clinical and pathological characteristics. Methods The expression of Gli-1 protein was detected by immunohistochemical staining(SP) in 65 cases with primary NSCLC and the matched normal lung tissues,and the clinical data were analyzed. Results The positive rate of Gli-1 was 76. 92% in NSCLC compared to the paired normal lung tissues (20. 00% ) with statistical significance( P = 0. 000) ; positive rate of Gli-1 correlated with tumor grade, clinical stage and age ( P < 0. 05 ). Conclusion Gli-1 may play a key role in the progression of NSCLC and its protein might serve as an important target for the therapeutic intervention in clinic.%探讨Gli-1蛋白在非小细胞肺癌(NSCLC)组织中的表达情况及临床意义.方法 应用免疫组化SP法检测65例NSCLC组织及其癌旁组织中Gli-1蛋白的表达,并结合患者的临床资料进行分析.结果 在NSCLC组织中Gli-1蛋白阳性表达率为76.92％(50/65),高于相应癌旁组织的20.00％( 13/65),差异有统计学意义(P=0.000).Gli-1蛋白阳性表达率与NSCLC患者的组织学分级、临床分期和年龄有显著的相关性(P＜0.05).结论 Gli-1可能在NSCLC的进展中起重要作用,其蛋白表达可以作为一项临床诊断的重要指标.
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