Objective:To analyze the correlation between the apolipoprotein A5 promoter and-1131T>C and 56C>G gene polymorphism and cerebral infarction in blood lipid levels.Methods:156 cases with cerebral infarction were selected from January 2012 to December 2013.We examined their serum lipid levels,and detected the A5 promoter-1131T>C and 56C>G gene polymorphisms of cerebral infarction by polymerase chain reaction.Results:The A5 promoter-1131T>C at different loci,the T frequency was 71.76%,the C frequency was 28.87%.There were no significant difference between HDL-C,LDL-C,TC and other factors have(P>0.05).There were apparent differences between carrying the C gene in TG and not carrying the C gene in TT(P<0.05).CG,CC genotype were in 56C>G,the frequency of relative allele G was 8.3%,the frequency of C was 91.7%,there was no significant difference in allele frequency and blood fat index(P>0.05).Conclusion:The level of TG in plasma of patients with cerebral infarction and the apolipoprotein A5 promoter-1131T and C gene polymorphism are closely related.%目的：分析脑梗死患者载脂蛋白A5启动子-1131T＞C及56C＞G基因与血脂水平的相关性以及其基因多态性。方法：2012年1月-2013年12月收治脑梗死患者156例，对其血脂水平进行检查，通过聚合酶链式反应对脑梗死的 A5启动子-1131T＞C 及56C＞G 基因多态性进行检测。结果：A5启动子-1131T＞C 在不同基因位点下，T 频率71.76%，C频率28.87%；本组研究人群中HDL-C、LDL-C、TC等因子之间比较差异无统计学意义(P＞0.05)；携带C基因人群的TG与没有携带C基因人群TT相比，差异有统计学意义(P＜0.05)；CG、CC基因型存在于56C＞G中，相关等位基因频率G8.3%，C频率91.7%，等位基因频率与血脂指标差异无统计学意义(P＞0.05)。结论：脑梗死患者血浆TG水平与载脂蛋白A5启动子-1131T＞C基因多态性有密切关系。
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