糖尿病肾脏疾病是糖尿病最常见的慢性微血管并发症之一,其患病率高,严重影响患者生活质量.对糖尿病肾脏疾病进行早期诊断及早期干预对改善患者预后、延缓疾病进展至关重要.尿微量白蛋白检测作为诊断早期糖尿病肾脏疾病的常用指标具有一定的局限性,而发现具有早期诊断和预测价值的新指标是临床和研究共同关注的重要问题.近年不断提出与糖尿病肾脏疾病发生和进展相关的生物标志物,包括肾小球、肾小管损伤相关指标,氧化应激与炎性因子,微小RNA及蛋白组学亦成为新的研究热点.本文就糖尿病肾脏疾病早期预测因子的研究进展进行综述.%Diabetic kidney disease (DKD) is one of the most common chronic microvascular complications of diabetes, which greatly affects the patients' quality of life. Early diagnosis and early treatment of DKD are of great importance to improve the prognosis and delay the progression of the disease. As a common indicator for the diagnosis of early DKD, urine microalbumin determination has some limitations, and identification of novel indicators for early diagnosis and prediction of DKD has high priority. Recently, novel biomarkers associated with the development and progression of DKD have been developed, including glomerular injury- and kidney tubular injury-associated markers. In addition, oxidative stress, inflammatory factors, microRNA, and proteomics have become important areas of DKD research. This review summarizes the advances in the research of early predictors of DKD.
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