Di-(2-ethylhexyl) phthalate(DEHP) is a plasticizer that is widely distributed in the environment. Epidemiological studies have shown that DEHP exposure is associated with insulin resistance,which in turn affects the occurrence of type 2 diabetes as well as metabolic syndrome.DEHP leads to insulin resistance through the insulin signaling pathway,the transcription factor peroxisome proliferators-activated receptor gamma (PPAR-γ) pathway,oxidative stress, lysosome-mitochondrial axis pathways and other metabolic risk factors.%邻苯二甲酸二(2-乙基)己酯(DEHP)是一种广泛分布于日常生活中的塑化剂.流行病学研究表明, DEHP暴露与胰岛素抵抗相关,而胰岛素抵抗又影响2型糖尿病和代谢综合征的发生.DEHP可通过胰岛素信号转导通路、转录因子过氧化物酶体增殖物激活受体γ(PPAR-γ)途径、氧化应激、溶酶体-线粒体轴途径及其他代谢危险因素导致胰岛素抵抗.
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