趋化运动是非兴奋细胞在趋化因子刺激下所发生的共同反应.神经元的趋化因子受体常通过激活三聚体G蛋白下游信号从而转导级联反应,进而活化分子信号转导通路.趋化因子及其受体在疼痛的发生和持续过程中起着重要作用.本文分别从趋化因子与神经系统的关系、趋化因子及其受体与疼痛的关系进一步分析了趋化因子及其受体在疼痛过程中的作用以及相关机制,同时为寻找和研发阻断趋化因子受体的药物以及疼痛治疗提供新的靶点.%Chemotaxis is a common response of non-excitable cells stimulated by chemokine.The chemokine receptor of neurons often transducts cascade via activating the heterotrimeric G protein downstream signals and further triggers molecular signal transduction pathway.Chemokines and their receptors play an important role in the occurrence and maintenance of pain.By analyzing the relationship between chemokines and nerve systems,the relationship between chemokines/chemokine receptors and pain,we demonstrated the mechanism of action of chemokines and their receptors in the pathogenesis of pain,suggesting that chemokines and their receptors are potential targets for the development of novel drugs and options for pain management.
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